Results 101 to 110 of about 364,113 (314)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Long-Term Trends in the Chemical and Mechanical Denudation in a Small Carpathian Catchment

Quaestiones Geographicae
Chemical and mechanical denudation are among the most important morphogenetic processes, especially in mountainous areas. The main objective of this study was to calculate the chemical deposition in precipitation as well as the chemical and mechanical ...
Kijowska-Strugała Małgorzata, Bochenek Witold, Wójcik Sabina   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial organization of genomic and epigenetic features.

, 2013
We used the 3D chromosomal structure BACH predicted for chromosome 2 in the HindIII sample as an illustrative example. In Figure 3A∼Figure 3L, each sphere represent a topological domain.
Jennifer Fang (274910), Ke Deng (278265), Bing Ren (78555), Zhaohui Qin (278266), Jesse Dixon (278267), Ming Hu (38573), Jun S. Liu (15013), Siddarth Selvaraj (278268)   +7 more
core   +1 more source

Signals, tracks, and trams: public transport signal priority impact on job accessibility over time

Scientific Reports
Improving travel time by public transport is a major task for city planners and policy makers to increase its competitiveness relative to cars which can be facilitated by implementing public transport preferential infrastructure treatments such as signal
Michał A. Niedzielski, Sławomir Goliszek, Anna Górka   +2 more
doaj   +1 more source

Unobvious geoheritage in sacral buildings: millstones in churches of NE Poland from a geological and geomorphological perspective

Geographia Polonica
The article highlights the importance of medieval churches with embedded millstones as geocultural objects with a great geotouristic and educational potential.
Piotr Czubla, Dariusz Brykała, Maciej Dąbski, Piotr Gierszewski, Mirosław Błaszkiewicz, Zachariasz Mosakowski, Piotr Lamparski   +6 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Functional Organization of Visual Cortex in the Owl Monkey

, 2004
In this study, we compared the organization of orientation preference in visual areas V1, V2, and V3. Within these visual areas, we also quantified the relationship between orientation preference and cytochrome oxidase (CO) staining patterns. V1 maps of
Shima, D., Bosking, W., Casagrande, V., Sáry, Gyula, Xu, X., Stefansic, J.   +5 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

SPATIAL STABILITY [PDF]

We consider a continuous spatial economy consisting of pure exchange local economies. Agents are allowed to change their location over time as a response to spatial utility differentials. These spatial adjustments toward higher utility neighborhoods lead
Pascal Mossay
core