Results 71 to 80 of about 310,752 (266)
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
European CountrysideThe research objective of the paper is to diagnose and assess knowledge transfer, taking place within rural areas as a consequence of contacts between rural inhabitants and the newcomers from towns.
Bański Jerzy +1 more
doaj +1 more source
Neighbouring the different: Social interaction in a Warsaw subarea
Bulletin of Geography. Socio-Economic Series, 2018 In the paper patterns of social interaction are examined, as shaped by an inflow of new residents to an inner-city subarea characterized by a low socio-economic status and featuring ethnic homogeneity. The empirical material is derived from a set of semi-
Korcelli-Olejniczak Ewa +1 more
doaj +1 more source
Peat core research in the Western Siberian Lowland: applications of palaeoecological proxies, regions studied, and future prospects [PDF]
Earth System Science DataPeatlands are natural archives that preserve information not only about their own development but also about past environmental conditions in surrounding landscapes.
A. Halaś, M. Słowiński
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Scientific DataWe share dataset of all general elections held in Poland between 1990 and 2024. These datasets correspond to two degrees of spatial aggregation: 41 constituencies for the Sejm and 94 for the Senate. In this dataset, for the first time, it was possible to
Przemysław Śleszyński +1 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Long-Term Trends in the Chemical and Mechanical Denudation in a Small Carpathian Catchment
Quaestiones GeographicaeChemical and mechanical denudation are among the most important morphogenetic processes, especially in mountainous areas. The main objective of this study was to calculate the chemical deposition in precipitation as well as the chemical and mechanical ...
Kijowska-Strugała Małgorzata +2 more
doaj +1 more source