Results 51 to 60 of about 3,956,063 (292)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Patients with Parkinson’s Disease Show Alteration in their Visuospatial Abilities and in their Egocentric and Allocentric Spatial Orientation Measured by Card Placing Tests

Journal of Parkinson’s Disease, 2020
Background: Visuospatial skills are impaired in Parkinson’s disease (PD). Other related skills exist, such as spatial orientation have been poorly studied.
Cristina Fernandez-Baizan, M. Paula Fernandez Garcia, Elena Diaz-Caceres, Manuel Menendez-Gonzalez, Jorge L. Arias, Marta Mendez   +5 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Use of geometry and featural cues in landmark configurations to reorient DCD children to the VR space: A route-learning study

Revista de Investigación e Innovación en Ciencias de la Salud, 2023
Background. Working memory-based spatial cognition has attracted the attention of the scientific community in navigation and reorientation projects.
Chrysanthi Basdekidou, Athanasios Styliadis, Alexandros Argyriadis, Levente Dimen   +3 more
doaj   +1 more source

Active navigation and orientation-free spatial representations [PDF]

, 2004
In this study, we examined the orientation dependency of spatial representations following various learning conditions. We assessed the spatial representations of human participants after they had learned a complex spatial layout via map learning, via ...
George S. W. Chan, Jennifer L. Campos, Chan, G., Sun, H., Hong-Jin Sun, Campos, J.   +5 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Think Spatially With Game Engine

ISPRS International Journal of Geo-Information, 2020
Spatial thinking and spatial orientation skills are involved in tasks related to the recognition of landforms, mapping, spatial interpretation, and landscape analysis, and can be developed with specific training.
Carlos Carbonell-Carrera, Peri Gunalp, Jose Luis Saorin, Stephany Hess-Medler   +3 more
doaj   +1 more source

The time course of adaptation to spatial contrast [PDF]

, 1991
We explored the buildup and decay of threshold elevation during and after adaptation to sinewave gratings in a series of experiments investigating the effects of adapting time, adapting contrast, spatial frequency and retinal eccentricity.
Harris, J. P., Georgeson, M. A., Magnussen, S., Greenlee, Mark W.   +3 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source