Results 81 to 90 of about 4,674,553 (309)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Land-use change simulation and assessment of driving factors in the loess hilly region - a case study as Pengyang County [PDF]
, 2010 The main objective of this study is to evaluate the land-use change and its relationship with its driving factors in the loess hilly region. In this study, a case study was carried out in Pengyang County.
Zhanqiang Zhu +9 more
core +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Regular pattern formation in real ecosystems [PDF]
, 2008 Localized ecological interactions can generate striking large-scale spatial patterns in ecosystems through spatial self-organization. Possible mechanisms include oscillating consumer–resource interactions, localized disturbance-recovery processes and ...
Koppel, Johan van de, +5 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Spatial Point Pattern Analysis and Industry Concentration [PDF]
Traditional measures of spatial industry concentration are restricted to given areal units. They do not make allowance for the fact that concentration may be differently pronounced at various geographical levels. Methods of spatial point pattern analysis
Hans-Friedrich Eckey +2 more
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Spatial patterns in species-rich sclerophyll shrublands of southwestern Australia [PDF]
, 2008 Question: The drivers of spatial patterning among plant species and the implications of those patterns for the structure and function of plant communities are of ongoing interest and debate.
B.B. Lamont +11 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Agri-Environmental Policies When the Spatial Pattern of Biodiversity Reserves Matters [PDF]
The aim of this paper is to compare different policy instruments for cost-effective habitat conservation on agricultural lands, when the desired spatial pattern of reserves is a random mosaic.
David, Maia +2 more
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Texas Pattern Jury Charges [PDF]
, 2011 Guide listing pattern jury charges to assist the bench and bar in preparing the court's charge for the jury in the state of Texas, including general instructions for the guilt/innocence and punishment stages of the trial, and instructions related to ...
State Bar of Texas. Committee on Pattern Jury Charges. +1 more
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