Results 111 to 120 of about 160,073 (300)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
How to explain the spatial evolution of new industries? The spatial evolution of the Dutch ICT industry [PDF]
In the paper, we concentrate on one of the most challenging issues of economic geography, that is, how to explain and analyze the evolution of the spatial pattern of new industries. First, we review the literature concerning this issue.
Boschma, Ron, Weterings, Anet
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Ecological IndicatorsSynergistic regional emission reduction (SRER) is an important part of the strategy to achieve carbon neutrality. In this paper, a system efficiency value-added model is proposed to measure the strength of SRER network relationships for 40,186 sets of ...
Bin Liao +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Cities and Satellites: Spatial Effects and Unobserved Heterogeneity in the Modeling of Urban Growth [PDF]
The confluence of factors driving urban growth is highly complex, resulting from a combination of ecological and social determinants that co-evolve over time and space.
Colin Vance, Rich Iovanna
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Reaction and diffusion on growing domains: Scenarios for robust pattern formation
, 1999 We investigate the sequence of patterns generated by a reaction—diffusion system on a growing domain. We derive a general evolution equation to incorporate domain growth in reaction—diffusion models and consider the case of slow and isotropic domain ...
Gaffney, Eamonn +10 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Spatial Externalities in Agriculture: Empirical Analysis, Statistical Identification, and Policy Implications [PDF]
Spatial externalities can affect economic welfare and landscape pattern by linking farm returns on adjoining parcels of land. While policy can be informed by research that documents spatial externalities, statistically quantifying the presence of ...
Barham, Bradford L. +2 more
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source