Results 11 to 20 of about 2,493 (227)

Comparison of dysgraphia impairments across writing-by-hand and two keyboard modalities

Frontiers in Psychology, 2015
Computer use is essential for tasks such as e-mail, banking and social networking and is important for communication and independence in persons with aphasia. However, most evaluations of dysgraphia have investigated handwriting exclusively.
Lisa A Edmonds, Jodi Morgan
doaj   +1 more source

Modeling effects of spatial patterns on the seed bank dynamics ofAlopecurus myosuroides

Weed Science, 1999
A spatially explicit metapopulation neighborhood model was extended to encompass the seed bank dynamics of the annual weedAlopecurus myosuroidesHuds. (blackgrass), growing in U.K. winter wheat crops established after noninversion tillage. The effects of the initial spatial pattern of infestation, herbicide, and combine harvesting on seed bank densities
Gonzales-Andujar, J. L., Perry, J. N., Moss, S. R.   +2 more
openaire   +1 more source

Filter Bank Common Spatial Pattern Algorithm on BCI Competition IV Datasets 2a and 2b [PDF]

Frontiers in Neuroscience, 2012
The Common Spatial Pattern (CSP) algorithm is an effective and popular method for classifying 2-class motor imagery electroencephalogram (EEG) data, but its effectiveness depends on the subject-specific frequency band. This paper presents the Filter Bank Common Spatial Pattern (FBCSP) algorithm to optimize the subject-specific frequency band for CSP on
Ang, Kai Keng, Chin, Zheng Yang, Wang, Chuanchu, Guan, Cuntai, Zhang, Haihong   +4 more
openaire   +3 more sources

Spatial and Temporal Fishing Patterns at the Outer Banks of the Southern California Bight

Western North American Naturalist, 2018
We analyzed recreational and commercial catch records from 1980 to 2009 for the fishing blocks associated with the 5 southern offshore banks of the Southern California Bight (Cortes Bank, Tanner Bank, Northeast Bank, Cherry Ridge, and Garrett Ridge). Recreational fishers and divers targeted pelagic taxa (e.g., tunas and Yellowtail) but instead landed ...
Daniel J. Pondella II, Matthew J. Robart, Jeremy T. Claisse, Jonathan P. Williams, Chelsea M. Williams, Amanda J. Zellmer, Susan E. Piacenza   +6 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source