Results 21 to 30 of about 2,964 (273)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Spatial Attributes and Patterns of Use in Household-Related Information and Communications Technology Activity [PDF]

, 2005
Information and communications technologies (ICTs) are affecting an ever-increasing array of household activities. Although considerable research has documented patterns of ICT use and sociodemographic profiles of ICT users, surprisingly little research
Yi Li, Kevin J. Krizek, Susan L. Handy
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Gender inequalities in India’s new service economy: a case study of the banking sector [PDF]

, 2012
PhDThis study explores women’s experiences of work and employment in the banking sector in India, addressing the paucity of research in this area. The research assesses how the assumptions of theories on gender, work and employment, primarily based on
Bezbaruah, Supriti
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Spatial Mobility in the Formation of Agent-Based Economic Networks [PDF]

, 2011
We extend the model of spatial social network formation of Johnson and Gilles (Review of Economic Design, 2000, 5, 273-299) by situating each economic agent within one of a set of discrete spatial locations and allowing agents to maximise the utility ...
Bullock, Seth, Zedan, Camillia, Ianni, Antonella   +2 more
core  

The impact of digital financial inclusion on bank performance: An exploration of mechanisms of action and heterogeneity.

PLoS ONE
The use of digital technology by banks and other financial institutions to facilitate financial inclusion is referred to as digital financial inclusion.
Jing Zhao, Congqi Wang, Haslindar Ibrahim, Yanpeng Chen   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Blockchain-Assisted Transformer CNN Framework with Optimal Feature Selection for Real-Time Digital Payment Fraud Detection

International Journal of Computational Intelligence Systems
The rapid growth of digital finance and e-commerce has led to an unprecedented surge in online transactions, making financial systems increasingly vulnerable to sophisticated and evolving fraudulent activities.
Himani Fnu, Mahamood Hussain Mirza, Mahatma Reddy Marri, Sangeeta Singh, Nitin Kumar, Dominic Majak Deng Adol, Rania M. Ghoniem, Ruby Pant, Salil Bharany   +8 more
doaj   +1 more source