Results 31 to 40 of about 2,964 (273)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Zróżnicowanie przestrzenne sieci bankowej w woj. dolnośląskim

Przedsiębiorczość - Edukacja, 2009
In this study, basic processes of changes in the Polish bank system in the period of economictransformation of the country are presented. It focuses on patterns of globalisation in banksector (e.g.
Paweł Brezdeń, Waldemar Spallek
doaj  

Optimizing neural networks for anomalous query detection in databases using the NSGA-II algorithm

Journal of Engineering and Applied Science
Database security has become a critical challenge due to the rapid increase in malicious queries that attempt to exploit vulnerabilities in database systems.
Xinpan Li
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Spatial mapping of banking systems: understanding the finance-space nexus in Germany and the UK [PDF]

Purpose In the aftermath of the Global Financial Crisis calls for the dismantling of too-big-to-fail institutions were widespread. Despite over a decade of regulatory reforms, there is limited empirical evidence regarding the downsizing of big banks in ...
Ivanov, P.
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Regeneration Strategies in Seed Plants: A Continuum Shaping Survival

Ecology and Evolution
Seed plants dominate terrestrial ecosystems in part because regeneration is not a single event, but a coordinated sequence of traits acting across time and space.
Keyvan Maleki, Elias Soltani
doaj   +1 more source

Spatial and temporal patterning of bank vole demography and the epidemiology of the Puumala hantavirus in northeastern France

Epidemiology and Infection, 2008
SUMMARYEpidemiological data from bank voles,Myodes glareolus, naturally infected by the hantavirus Puumala (PUUV) were collected by a capture–mark–recapture protocol from 2000 to 2002 in the French department of Ardennes. Four monitored trapping sites were established in two forests located in two cantons (Flize and Monthermé).
D, Augot, F, Sauvage, F, Boue, M, Bouloy, M, Artois, J M, Demerson, B, Combes, D, Coudrier, H, Zeller, F, Cliquet, D, Pontier   +10 more
openaire   +3 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source