Results 31 to 40 of about 186,099 (245)

Framework for collaborative local climate adaptation scenario development- nexus between climate resilience, public health service and spatial planning [PDF]

International Journal of Climate Change Strategies and Management
Purpose – The interaction between urban development and climate change significantly impacts local public health services. Unfortunately, cities and involved institutions often fail to prioritize and integrate spatial planning when dealing with these ...
Wiriya Puntub, Stefan Greiving, Joern Birkmann   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Transition of mobility in companies – A semi-systematic literature review and bibliographic analysis on corporate mobility and its management

Transportation Research Interdisciplinary Perspectives, 2021
Advancement measures and negative externalities of the current transport system have been extensively researched but significant changes concerning greenhouse gas (GHG) emission reduction is yet to be achieved. The expected mobility changes, triggered by
Tobias Gorges, Christian Holz-Rau
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

An open risk index with learning indicators from OSM-tags, developed by machine learning and trained with the WorldRiskIndex [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019
While climate change is already a real issue in many parts of the world, it is even more threatening the well-being of future generations. The SDG 1.5 explicitly aims to reduce the vulnerability and exposure to climate related hazards by 2030.
D. Feldmeyer, H. Sauter, J. Birkmann
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Between author’s dreams and client’s wishes

Actas de Arquitectura Religiosa Contemporánea
Contemporary praxis of church construction in the Serbian Orthodox Church (SOC) and the client-architect relationship are conditioned by Church tradition and regulations.
Božidar Mani´c , Ana Nikovi´c, Boško Josimovi´c   +2 more
doaj   +1 more source

Relationship between traditional and contemporary elements in the architecture of Orthodox churches at the turn of the millennium [PDF]

Facta Universitatis. Series: Architecture and Civil Engineering, 2015
The paper will present the contemporary practice of church architecture in Bulgarian, Romanian, Russian and Greek orthodox churches, at the end of the XX and the beginning of the XXI century, and analyse the relationship of traditional and ...
Manić Božidar, Niković Ana, Marić Igor   +2 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source