Results 61 to 70 of about 23,439 (262)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Enabling Semantic Queries Against the Spatial Database

Advances in Electrical and Computer Engineering, 2012
The spatial database based upon the object-relational database management system (ORDBMS) has the merits of a clear data model, good operability and high query efficiency. That is why it has been widely used in spatial data organization and management.
PENG, X., HUANG, Z.
doaj   +1 more source

Distance-Constraint k-Nearest Neighbor Searching in Mobile Sensor Networks

Sensors, 2015
The κ -Nearest Neighbors ( κNN) query is an important spatial query in mobile sensor networks. In this work we extend κNN to include a distance constraint, calling it a l-distant κ-nearest-neighbors ( l ...
Yongkoo Han, Kisung Park, Jihye Hong, Noor Ulamin, Young-Koo Lee   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Error-bounded and Number-bounded Approximate Spatial Query for Interactive Visualization

Open Geosciences, 2018
In the big data era, an enormous amount of spatial and spatiotemporal data are generated every day. However, spatial query result sets that satisfy a query condition are very large, sometimes over hundreds or thousands of terabytes.
Qiu Agen, Zhang Zhiran, Qian Xinlin, He Wangjun   +3 more
doaj   +1 more source

Distributed Processing of Location-Based Aggregate Queries Using MapReduce

ISPRS International Journal of Geo-Information, 2019
The location-based aggregate queries, consisting of the shortest average distance query (SAvgDQ), the shortest minimal distance query (SMinDQ), the shortest maximal distance query (SMaxDQ), and the shortest sum distance query (SSumDQ) are new types of ...
Yuan-Ko Huang
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Probabilistic CkNN Queries of Uncertain Data in Large Road Networks

IEEE Access, 2016
Continuous k-nearest neighbor (CkNN) query processing is an important issue in spatial temporal databases. In real-world scenarios, query clients and data objects may move with uncertain speeds on the road networks, which makes retrieving the exact CkNN ...
Yanhong Li, Rongbo Zhu, Guohui Li, Lihchyun Shu, Changyin Luo   +4 more
doaj   +1 more source

Efficient Processing of Spatial Keyword Queries

, 2015
Massive amount of data that are geo-tagged and associated with text information are being generated at an unprecedented scale in many emerging applications such as location based services and social networks. Due to their importance, a large body of work has focused on efficiently computing various spatial keyword queries.
openaire   +2 more sources