Results 61 to 70 of about 23,651 (261)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Enabling Semantic Queries Against the Spatial Database
Advances in Electrical and Computer Engineering, 2012 The spatial database based upon the object-relational database management system (ORDBMS) has the merits of a clear data model, good operability and high query efficiency. That is why it has been widely used in spatial data organization and management.
PENG, X., HUANG, Z.
doaj +1 more source
Distance-Constraint k-Nearest Neighbor Searching in Mobile Sensor Networks
Sensors, 2015 The κ -Nearest Neighbors ( κNN) query is an important spatial query in mobile sensor networks. In this work we extend κNN to include a distance constraint, calling it a l-distant κ-nearest-neighbors ( l ...
Yongkoo Han +4 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Error-bounded and Number-bounded Approximate Spatial Query for Interactive Visualization
Open Geosciences, 2018 In the big data era, an enormous amount of spatial and spatiotemporal data are generated every day. However, spatial query result sets that satisfy a query condition are very large, sometimes over hundreds or thousands of terabytes.
Qiu Agen +3 more
doaj +1 more source
Distributed Processing of Location-Based Aggregate Queries Using MapReduce
ISPRS International Journal of Geo-Information, 2019 The location-based aggregate queries, consisting of the shortest average distance query (SAvgDQ), the shortest minimal distance query (SMinDQ), the shortest maximal distance query (SMaxDQ), and the shortest sum distance query (SSumDQ) are new types of ...
Yuan-Ko Huang
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Probabilistic CkNN Queries of Uncertain Data in Large Road Networks
IEEE Access, 2016 Continuous k-nearest neighbor (CkNN) query processing is an important issue in spatial temporal databases. In real-world scenarios, query clients and data objects may move with uncertain speeds on the road networks, which makes retrieving the exact CkNN ...
Yanhong Li +4 more
doaj +1 more source
Efficient Processing of Spatial Keyword Queries
, 2015 Massive amount of data that are geo-tagged and associated with text information are being generated at an unprecedented scale in many emerging applications such as location based services and social networks. Due to their importance, a large body of work has focused on efficiently computing various spatial keyword queries.
openaire +2 more sources