Results 61 to 70 of about 25,759 (265)
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Error-bounded and Number-bounded Approximate Spatial Query for Interactive Visualization
Open Geosciences, 2018 In the big data era, an enormous amount of spatial and spatiotemporal data are generated every day. However, spatial query result sets that satisfy a query condition are very large, sometimes over hundreds or thousands of terabytes.
Qiu Agen +3 more
doaj +1 more source
Distributed Processing of Location-Based Aggregate Queries Using MapReduce
ISPRS International Journal of Geo-Information, 2019 The location-based aggregate queries, consisting of the shortest average distance query (SAvgDQ), the shortest minimal distance query (SMinDQ), the shortest maximal distance query (SMaxDQ), and the shortest sum distance query (SSumDQ) are new types of ...
Yuan-Ko Huang
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Probabilistic CkNN Queries of Uncertain Data in Large Road Networks
IEEE Access, 2016 Continuous k-nearest neighbor (CkNN) query processing is an important issue in spatial temporal databases. In real-world scenarios, query clients and data objects may move with uncertain speeds on the road networks, which makes retrieving the exact CkNN ...
Yanhong Li +4 more
doaj +1 more source
Efficient Processing of Spatial Keyword Queries
, 2015 Massive amount of data that are geo-tagged and associated with text information are being generated at an unprecedented scale in many emerging applications such as location based services and social networks. Due to their importance, a large body of work has focused on efficiently computing various spatial keyword queries.
openaire +2 more sources
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Distance-Constraint k-Nearest Neighbor Searching in Mobile Sensor Networks
Sensors, 2015 The κ -Nearest Neighbors ( κNN) query is an important spatial query in mobile sensor networks. In this work we extend κNN to include a distance constraint, calling it a l-distant κ-nearest-neighbors ( l ...
Yongkoo Han +4 more
doaj +1 more source
Query processing of spatial objects: Complexity versus redundancy [PDF]
, 1993 The management of complex spatial objects in applications, such as geography and cartography, imposes stringent new requirements on spatial database systems, in particular on efficient query processing. As shown before, the performance of spatial query processing can be improved by decomposing complex spatial objects into simple components.
Schiwietz, Michael, Kriegel, Hans-Peter
openaire +2 more sources
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source