Results 41 to 50 of about 25,759 (265)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
ISPRS International Journal of Geo-Information, 2017 Geospatial big data analysis (GBDA) is extremely significant for time-constraint applications such as disaster response. However, the time-constraint analysis is not yet a trivial task in the cloud computing environment. Spatial query processing (SQP) is
Wei Huang +3 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
A KNN Dynamic Extended Query Strategy Based on GPU [PDF]
Jisuanji gongcheng, 2018 Traditional Graphics Processing Unit(GPU) executing PGrid index K-Nearest Neighbor(KNN) query method has problems such as large query granularity,redundant calculation,and unstable performance.Therefore,facing spatial KNN relation queries,a KNN query ...
TANG Jia,GONG Yili,LI Wenhai
doaj +1 more source
Query Processing of Geosocial Data in Location-Based Social Networks
ISPRS International Journal of Geo-Information, 2021 The increasing use of social media and the recent advances in geo-positioning technologies have produced a great amount of geosocial data, consisting of spatial, textual, and social information, to be managed and queried.
Arianna D’Ulizia +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
OPTIMIZATION OF LOCATION BASED QUERIES USING SPATIAL INDEXING [PDF]
ICTACT Journal on Soft Computing, 2014 The recent development in the technology leads to the introduction of various mobile terminals and there is a demand that the client requires effective location based services.
S. Geetha, S. Anu Velavan
doaj