Results 51 to 60 of about 25,759 (265)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
IB-CBB: an improved spatial index considering intersection based on clipped bounding boxes
Annals of GISEfficiently querying multiple spatial datasets is a challenging task in geoscience. The majority of spatial processing techniques use minimum bounding box (MBB) to approximate neighbouring spatial objects and and place them adjacent in the spatial index.
Wei Xiong +3 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Top-k Spatial Preference Queries in Directed Road Networks
ISPRS International Journal of Geo-Information, 2016 Top-k spatial preference queries rank objects based on the score of feature objects in their spatial neighborhood. Top-k preference queries are crucial for a wide range of location based services such as hotel browsing and apartment searching.
Muhammad Attique +3 more
doaj +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
A SPEED-UP GEOMETRIC CHANGE DETECTION ALGORITHM FOR VECTOR SURFACE FEATURE SET [PDF]
ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2018 At present, most of the researches on geometric change detection of vector data, they store the change detection results in the database, so they pay more attention to the accuracy of results, but not to the speed of processing.
L. Zhu +5 more
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Enabling Semantic Queries Against the Spatial Database
Advances in Electrical and Computer Engineering, 2012 The spatial database based upon the object-relational database management system (ORDBMS) has the merits of a clear data model, good operability and high query efficiency. That is why it has been widely used in spatial data organization and management.
PENG, X., HUANG, Z.
doaj +1 more source