Results 91 to 100 of about 47,554 (301)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Spatial factors and the employment of blacks at the firm level [PDF]

open access: yes
In this paper we use data from a new survey of over 3,000 employers in four major metropolitan areas to investigate the determinants of black employment and wages at the firm level.
K. R. Ihlanfeldt, H. J. Holzer
core  

Spatial Variability in Seasonal Prediction Skill of SSTs: Inherent Predictability or Forecast Errors?

open access: yes, 2018
Seasonal prediction skill of SSTs from coupled models has considerable spatial variations. In the tropics, SST prediction skill in the tropical Pacific clearly exceeds prediction skill over the Atlantic and Indian Oceans.
Jieshun Zhu, Arun Kumar
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Erratum: Spatial Skills Associated With Block-Building Complexity in Preschoolers

open access: yesFrontiers in Psychology, 2021
Frontiers Production Office
doaj   +1 more source

Skill gaps in the EU: role for education and training policies [PDF]

open access: yes
Skill gaps are widely seen as a problem that lowers aggregate productivity growth. A question for the European Commission is whether and how governments should take action with education and training policies to reduce skill gaps and make Europe the best
Marc van der Steeg   +2 more
core  

The effect of the spatial skills education program on the spatial skills of preschool children

open access: yes, 2014
Spatial skills have a central place in humans’ process of adaptation to their environment. Gaining of spatial experiences in the early childhood constitutes the basis for children’s learning experiences in the following periods. Preschool learning environments provide important opportunities to children (games and communication with friends and ...
Adak Özdemir, Atiye, Güven, Yıldız
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Using climate regionalization to understand Climate Forecast System Version 2 (CFSv2) precipitation performance for the Conterminous United States (CONUS)

open access: yesGeophysical Research Letters, 2016
Dynamically based seasonal forecasts are prone to systematic spatial biases due to imperfections in the underlying global climate model (GCM). This can result in low‐forecast skill when the GCM misplaces teleconnections or fails to resolve geographic ...
Satish K. Regonda   +3 more
doaj   +1 more source

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