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فاعلية استخدام برنامج ماتلاب (MATLAB) مع السبورة التفاعلية على التحصيل وتنمية القدرة المکانية ومفهوم الذات الرياضياتية لدى طالبات الصف الثالث الثانوي [PDF]

مجلة تربويات الرياضيات, 2019
هدفت الدراسة إلى معرفة فاعلية استخدام برنامج ماتلاب (MATLAB) مع السبورة التفاعلية على التحصيل وتنمية القدرة المکانية ومفهوم الذات الرياضياتية لدى طالبات الصف الثالث الثانوي.
منيرة بنت حميد سالم العلوني
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Spatial skills first: The importance of mental rotation for arithmetic skill acquisition

Journal of Numerical Cognition, 2019
Considering the importance of arithmetic in school curricula, it is crucial to understand the cognitive processes underlying its successful acquisition. Previous research suggests the involvement of spatial skills, especially during arithmetic skill acquisition.
Carrie Georges, Véronique Cornu, Christine Schiltz   +2 more
openaire   +5 more sources

The Development of Spatial Skills in Elementary School Students [PDF]

Child Development, 2018
Abstract Through five waves of data collection, this longitudinal study investigated the development of spatial skills in 304 elementary school children (Mage = 7.64 years) as they progressed from the second to fourth grade. The study focused on whether multiple latent classes with different developmental profiles best explain ...
Martha Carr, Natalia Alexeev, Lu Wang, Nicole Barned, Erin Horan, Adam Reed   +5 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Forecast Skill of the Arctic Sea Ice Outlook 2008–2022

Geophysical Research Letters, 2023
We assess the skill of forecasts of Arctic September sea ice in the Sea Ice Outlook over 2008–2022. The multi‐model median June initialized forecast of September sea ice extent (SIE) is slightly more skilled (RMSE = 0.48 million km2) than a damped ...
Edward Blanchard‐Wrigglesworth, Mitchell Bushuk, François Massonnet, Lawrence C. Hamilton, Cecilia M. Bitz, Walter N. Meier, Uma S. Bhatt   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source