Results 51 to 60 of about 1,471,906 (260)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Temporal and Spatial Evolution Analysis of Earthquake Events in California and Nevada Based on Spatial Statistics

ISPRS International Journal of Geo-Information, 2021
Studying the temporal and spatial evolution trends in earthquakes in an area is beneficial for determining the earthquake risk of the area so that local governments can make the correct decisions for disaster prevention and reduction.
Weifeng Shan, Zhihao Wang, Yuntian Teng, Maofa Wang   +3 more
doaj   +1 more source

Log-Poisson Statistics and Extended Self-Similarity in Driven Dissipative Systems

, 2004
The Bak-Chen-Tang forest fire model was proposed as a toy model of turbulent systems, where energy (in the form of trees) is injected uniformly and globally, but is dissipated (burns) locally.
Bak, Bak, Benzi, Bröker, C Jayaprakash, Chen, Chen, Dubrulle, Frisch, Grassberger, Kan Chen, Kinzel, Kolmogorov, Kolmogorov, Obukhov, Parisi, She, Sreenivasan   +17 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Identification of flooding susceptible areas by soil infiltration spatial correlation patterns [PDF]

مخاطرات محیط طبیعی, 2019
Soil properties at the lands lot scale is a process that effects on infiltration rates, which can lead to an increased stormwater runoff. Sustainable land management for runoff controls requires reliable information on the spatial distribution of soil ...
Mohamad sadegh Oliaei, Ali Barikloo, Moslem Servati   +2 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Identifying Spatial Variability in Greenland's Outlet Glacier Response to Ocean Heat

Frontiers in Earth Science, 2018
Although the Greenland ice sheet is losing mass as a whole, patterns of change on both local and regional scales are complex. Spatial statistics reveal large spatial variability of dynamic thinning rates of Greenland's marine-terminating glaciers between
David F. Porter, Kirsty J. Tinto, Alexandra L. Boghosian, Beata M. Csatho, Robin E. Bell, James R. Cochran   +5 more
doaj   +1 more source

Analysis of Spatially Distributed Data in Internet of Things in the Environmental Context

Sensors, 2022
The Internet of Things consists of “things” made up of small sensors and actuators capable of interacting with the environment. The combination of devices with sensor networks and Internet access enables the communication between the physical world and ...
Leonildo José de Melo de Azevedo, Júlio Cezar Estrella, Alexandre C. B. Delbem, Rodolfo Ipolito Meneguette, Stephan Reiff-Marganiec, Sidgley Camargo de Andrade   +5 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Social Networks and Social Cohesion in the Netherlands: Insights from Combined Administrative and Survey Data

Social Sciences
Statistics Netherlands (CBS) has recently developed the whole population network (Person Network) file, based on administrative microdata, which includes over a billion interpersonal relationships among approximately 17 million inhabitants of the ...
Dino Pitoski, Hans Schmeets
doaj   +1 more source