Results 111 to 120 of about 16,214,189 (289)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The policy landscape of agrivoltaics: a systematic review

Energy, Sustainability and Society
Background Agrivoltaics, the dual use of land for both agriculture and solar energy production, has gained increasing attention in recent years. However, its large-scale implementation is constrained by policy challenges.
André Alves, Eduarda Marques da Costa, Igor Sirnik   +2 more
doaj   +1 more source

Enhancing GeoHealth: A step-by-step procedure for spatiotemporal disease mapping

Geospatial Health
Cartography, or geographical visualization of disease is an essential aspect of the field of GeoHealth, yet there is limited guidance on the visualization of spatiotemporal disease maps.
Bart Roelofs, Gerd Weitkamp
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Spatial studies on vector-transmitted diseases and vectors. [PDF]

J Trop Med, 2012
Rosa-Freitas MG, Honório NA, Codeço CT, Werneck GL, Degallier N.   +4 more
europepmc   +1 more source

Improving the Walkability of High Streets: A Participatory Approach Using Biosensing and Scenario Co-Creation

Urban Science
In the 21st century, there has been a concerted effort to undo the automobile-centric urban planning of the 20th century, which has resulted in degraded public spaces that deter citizen permanence.
Tomás Pedro, Daniel Paiva
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Workbook for Quantitative Methods and Socio-Economic Applications in GIS

This webinar will introduce the project on "the Workbook for Quantitative Methods and Socioconomic Application in GIS", and how to join the spatial data lab on those ongoing spacial social science research and development ...
Spatial, Data Lab
core   +1 more source

Description and spatial analysis of employment change in New Zealand regions 1986-2001 [PDF]

, 2005
Over the last two decades New Zealand has undergone fundamental economic restructuring, and phases of slow and rapid growth, which have resulted in some dramatic changes in the regional economies.
Baxendine, Sandra, Poot, Jacques, Cochrane, William   +2 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source