Results 151 to 160 of about 71,340 (293)
Non‐Invasive Brain Targeted Delivery of Cannabidiol for Alleviating Neuroinflammatory Disease
Advanced Materials, EarlyView.The glucose‐functionalized nanoparticles (GNPs) are developed for the brain‐targeted delivery of cannabidiol (CBD). GNPs bypass the blood‐brain barrier (BBB) via glucose transporter‐1 (GLUT‐1) and release CBD in response to reactive oxygen species (ROS).
Yibin Wang +7 more
wiley +1 more source
Advanced Materials, EarlyView.A nano‐interception strategy disrupts pathogenic fibroblast–macrophage crosstalk in chronic heart failure. Scalable Prussian blue nanoparticles selectively sequester CCL2 via ultrahigh‐affinity binding, preventing CCR2+ macrophage recruitment and breaking a key fibro‐inflammatory circuit. This approach demonstrates robust efficacy in murine and porcine
Bo Chen +16 more
wiley +1 more source
Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming
Advanced Materials, EarlyView.Matrix viscoelasticity is a key mechanical feature of the tumor microenvironment but remains poorly understood in immune regulation. Here, we develop a tunable collagen platform to decouple viscoelasticity from stiffness and show that slow‐relaxing matrices constrain dendritic cell migration by limiting actomyosin‐driven matrix remodeling, thereby ...
Wei‐Hung Jung +6 more
wiley +1 more source
Advanced Materials, EarlyView.ABSTRACT Bone tissue regeneration is a complex physiological process dependent on the spatiotemporal coordination of immune cells and stem cells. Conventional research primarily elucidates the mechanism through which materials facilitate bone formation by initially modulating macrophages and subsequently encouraging the osteogenic differentiation of ...
Yang Lu +11 more
wiley +1 more source
Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues
Advanced Materials Interfaces, EarlyView.ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike +3 more
wiley +1 more source
Advanced Materials Technologies, EarlyView.A 3D Matrigel‐based droplet microfluidics platform that allows physiologically relevant analysis of single immune‐tumor interactions in solid tumors. By integrating real‐time functional imaging with fluorescence‐activated droplet sorting and RNA sequencing, the system links immune cytotoxic behavior to transcriptomic profiles, providing a scalable ...
Christina Sharkey +6 more
wiley +1 more source
Spatial transcriptomics herald a new era of transcriptome research
Clinical and Translational Medicine, 2023 Dominik Saul, Robyn Laura Kosinsky
openaire +3 more sources
Advanced Science, EarlyView.Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater +13 more
wiley +1 more source
Advanced Science, EarlyView.Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun +7 more
wiley +1 more source
Advances in Spatial Transcriptomics in Bone. [PDF]
Curr Osteoporos RepGiger NV, Wehrle E.
europepmc +1 more source