Results 241 to 250 of about 71,340 (293)

Editorial: Unraveling breast cancer complexity: insights from single-cell sequencing and spatial transcriptomics. [PDF]

Front Immunol
Kartikasari AER, Decock J.
europepmc   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

A comparative study of statistical methods for identifying differentially expressed genes in spatial transcriptomics. [PDF]

PLoS Comput Biol
Wang Y, Zang C, Li Z, Guo CC, Lai D, Wei P.   +5 more
europepmc   +1 more source

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

PathCLAST: pathway-augmented contrastive learning with attention for interpretable spatial transcriptomics. [PDF]

Brief Bioinform
Noh M, Lee S, Kim S, Lim S.
europepmc   +1 more source

Spatial transcriptomics reveals the molecular signatures of prodromal and advanced α-synucleinopathy. [PDF]

iScience
Lin L, Jensen NM, Delaidelli A, Ferreira SA, Yarmahmoudi F, Sorensen PH, Romero-Ramos M, Jensen PH, Mackenzie IR, Nyengaard JR, Jan A.   +10 more
europepmc   +1 more source

Applications of AI to single-cell and spatial transcriptomics: current state-of-the-art and challenges. [PDF]

Front Bioinform
Tchatchoua Ngassam B, Niu H, Pang S, Shydlouskaya V, Andrews TS.   +4 more
europepmc   +1 more source

Correction: CiCLoDS: Joint cell clustering and gene selection for single-cell spatial transcriptomics. [PDF]

Sci Rep
Wang N, He Y, Ray E, Won KJ, Cetrulo CL, Li D, Moore JH, Zhang S, Huang X.   +8 more
europepmc   +1 more source