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Spatially resolved transcriptomics and beyond
Nature Reviews Genetics, 2014Considerable progress in sequencing technologies makes it now possible to study the genomic and transcriptomic landscape of single cells. However, to better understand the complexity of multicellular organisms, we must devise ways to perform high-throughput measurements while preserving spatial information about the tissue context or subcellular ...
Crosetto N, Bienko M, van Oudenaarden A
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Spatial transcriptomics in health and disease
Nature Reviews NephrologyThe ability to localize hundreds of macromolecules to discrete locations, structures and cell types in a tissue is a powerful approach to understand the cellular and spatial organization of an organ. Spatially resolved transcriptomic technologies enable mapping of transcripts at single-cell or near single-cell resolution in a multiplex manner.
Sanjay Jain, Michael T. Eadon
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Spatial Transcriptomic Analyses of Spermatogenesis
Measuring mRNA abundance at the level of the whole transcriptome has become an indispensable tool for the investigation of fundamental biological processes in higher eukaryotes. However, traditional transcriptomic methods are destructive and ignore the three-dimensional organization of cells within tissues and organs.Ndifereke, Uboh +3 more
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Spatial transcriptomic applications in orthopedics
Connective Tissue ResearchThis review highlights the transformative impact of spatial transcriptomics on orthopedic research, focusing on its application in deciphering intricate gene expression patterns within musculoskeletal tissues.The paper reviews literature for spatial transcriptomic methods, specifically 10X Visium, 10X Xenium, seqFISH+, MERFISH, NanoString GeoMx DSP ...
Thomas L. Jenkins +2 more
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Spatial transcriptomics in glomerular diseases
RheumatologyAbstract Spatial transcriptomics enables the study of the mechanisms of disease through gene expression and pathway activity analysis in a spatial context. Originally mainly employed in oncology, the techniques developed use different methods of transcript identification, resolution (single cells vs regions), flexibility of target ...
Renate Kain, André Oszwald
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A practical guide to spatial transcriptomics
Molecular Aspects of MedicineSpatial transcriptomics is revolutionizing modern biology, offering researchers an unprecedented ability to unravel intricate gene expression patterns within tissues. From pioneering techniques to newly commercialized platforms, the field of spatial transcriptomics has evolved rapidly, ushering in a new era of understanding across various disciplines ...
Lukas Valihrach +3 more
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Exploring tissue architecture using spatial transcriptomics
Nature, 2021Dalia Barkley, Anjali Rao, Itai Yanai
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