Results 211 to 220 of about 45,113 (260)

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan, Yitong Li, Yufei Wu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang   +6 more
wiley   +1 more source

Integrated single-cell and spatial transcriptomics reveal immune landscape and NKT-Th1 signatures in colorectal cancer. [PDF]

Front Immunol
Wu C, Xu Y, Zhao M, Tao L, Duan DD, Qian J, Zhao S, Liu S, Zhou JY.   +8 more
europepmc   +1 more source

A Sprayable Nanoplatform Breaks the Vicious Cycle of Diabetic Wounds via Photoactivated Antioxidant and Drug Delivery

Advanced Science, EarlyView.
A sprayable near‐infrared‐activated nanoplatform incorporating MXene, ZnHCF nanozyme, and deferoxamine efficiently breaks the vicious cycle of diabetic wounds. Upon irradiation, interfacial electron transfer and photothermal effects enhance multi‐enzyme activity, enabling explosive ROS elimination, alleviation of hypoxia, and controlled DFO release ...
Jiahao Guo, Yuanyuan Meng, Qixiang Gui, Xi‐Tao Yang, Yong Fan, Xiaodong Zhu   +5 more
wiley   +1 more source

Neoplastic CD3⁺ B cells remodel the DLBCL tumor microenvironment via single-cell and spatial transcriptomics. [PDF]

Cancer Biol Ther
Lang M, Feng Y, Zhou L, Li B, Li W, Zhao J, Chen K, Li L, Qiu L, Qian Z, Zhou S, Zhang H, Chu Z.   +12 more
europepmc   +1 more source

Spatial transcriptomics in the human adult ovary: insights into key signalling pathways during follicular atresia. [PDF]

Hum Reprod
Vlieghe H, Wei F, Cheng H, Stolk THR, Huirne JA, van Mello NM, Amorim CA, Chuva de Sousa Lopes SM.   +7 more
europepmc   +1 more source

Pan-cancer analysis of spatial transcriptomics reveals heterogeneous tumor spatial microenvironment. [PDF]

Cell Rep Med
Li J, Lin P, Wang H, Tang Z, Yan X, Chen X, Yuan J, Chen W, Li H.   +8 more
europepmc   +1 more source

Reconstructing single-cell resolution from spatial transcriptomics with CellRefiner. [PDF]

Nat Commun
Bourgain-Chang E, Kuang X, Cang Z, Nie Q.   +3 more
europepmc   +1 more source

Developing a Single-Cell Spatial Transcriptomics Workflow for In Vivo Evaluation of Implanted Biomaterials. [PDF]

Adv Sci (Weinh)
Chan AHP, Hu Y, Pardavi B, Xu X, Grant AJ, Wise SG, Loo L, Tan RP.   +7 more
europepmc   +1 more source

A spatial transcriptomics comparison of the adult versus metamorphosed axolotl brain. [PDF]

Sci Data
Wang S, Fu S, Liu X, Zeng YY, Zhang L, Zhang N, Dai X, Li H, Gu Y, Wei X, Fei JF, Liu Y.   +11 more
europepmc   +1 more source

A Targeted Spatial Transcriptomics Framework for a High-Resolution Human Skin Cell Atlas

Peake M, Langton A, Farrar M, Mambwe B, Kiss O, Duan W, Chandidzura A, Cotterell L, Halai P, Thomas D, O'Neill C, O'Connor C, Bell M.   +12 more
europepmc   +1 more source