Results 201 to 210 of about 45,113 (260)

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

ST2HE: enhancing spatial transcriptomics interpretability via virtual staining for histological annotation. [PDF]

Brief Bioinform
Liu Z, Das A, Meng W, Chiu YC, Gao SJ, Huang Y.   +5 more
europepmc   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Spatial transcriptomics uncovers TAC-OGEs heterogeneity and FN1/MMP9 signature in ameloblastoma. [PDF]

Front Immunol
Wang Y, Li H, Zhang C, Peng X, Liu J, Du W, Yu Y, Hou Y, Li X.   +8 more
europepmc   +1 more source

Artificial Intelligence‐Based Body Composition Analysis Reveals Sex‐Specific Prognostic Markers and Their Clinical Value in Gastric Cancer: A Multicenter Study

Advanced Science, EarlyView.
This study applied AI to quantify multidimensional body composition from CT images in gastric cancer and healthy controls. Distinct sex‐specific patterns and disease‐related alterations were identified and were associated with survival. Higher muscle and fat measures were linked to improved outcomes.
Tianxiang Li, Tingting Liu, Qian Yang, Zhiqing Zhang, Xiaofang Guo, Xiang Wang, Yihan Zhang, Limin Ge, Yu Su, Wenjun Wu, Weihua Guo, Zheng Wang, Lian Yang, Yanfeng Niu   +13 more
wiley   +1 more source

DiSCO: deconvoluting spatial transcriptomics via combinatorial optimization with a foundational diffusion model. [PDF]

Brief Bioinform
Liu J, Wu Y, Li L.
europepmc   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Orchestrating Spatial Transcriptomics Analysis with Bioconductor

Crowell HL, Dong Y, Billato I, Cai P, Emons M, Gunz S, Guo B, Li M, Mahmoud A, Manukyan A, Pagès H, Panwar P, Rao S, Sargeant CJ, Shepherd Kern L, Ramos M, Sun J, Totty M, Carey VJ, Chen Y, Collado-Torres L, Ghazanfar S, Hansen KD, Martinowich K, Maynard KR, Patrick E, Righelli D, Risso D, Tiberi S, Waldron L, Gottardo R, Robinson MD, Hicks SC, Weber LM.   +33 more
europepmc   +1 more source

Spatial transcriptomics reveals a molecular tumor budding signature in head and neck cancer. [PDF]

Genome Med
Ourailidis I, Ball M, Vogel V, He M, Wang H, Kim SB, Böning S, Wollenberg B, Wolff KD, Steiger K, Mogler C, Duensing A, Duensing S, Schirmacher P, Stenzinger A, Gires O, Kazdal D, Kirchner M, Stögbauer F, Boxberg M, Budczies J.   +20 more
europepmc   +1 more source