Results 91 to 100 of about 7,213,322 (346)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
, 2018 Getting the overall picture of how a large number of ego-networks evolve is a common yet challenging task. Existing techniques often require analysts to inspect the evolution patterns of ego-networks one after another.
Basole, Rahul C. +2 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Spatial patterns of trends in seasonal extreme temperatures in India during 1980–2010
Weather and Climate Extremes, 2019 Station level daily maximum and minimum temperature data spread across India were analyzed for trends in seasonal extreme temperature indices. The trends were calculated for the recent period of 1980–2010, when some of the warmest temperatures were ...
Shouraseni Sen Roy
doaj +1 more source
Temporal and Spatial Patterns in the Prehistoric Settlement of the Lake Bob Sandlin Area, Big Cypress Creek Basin, Northeastern Texas [PDF]
, 2003 Since many of the archeological sites documented during the course of previous archeological investigations at Lake Bob Sandlin contain temporally diagnostic lithic, ceramic, and/or historic artifacts, we have the opportunity to investigate prehistoric ...
Nelson, Bo, Perttula, Timothy K.
core +1 more source
Downscaling extremes: A comparison of extreme value distributions in point-source and gridded precipitation data [PDF]
, 2010 There is substantial empirical and climatological evidence that precipitation extremes have become more extreme during the twentieth century, and that this trend is likely to continue as global warming becomes more intense.
Cooley, Daniel +4 more
core +4 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Spatial and temporal variablity of nonmethane hydrocarbon mixing ratios and their relation to photochemical lifetime [PDF]
, 1998 The relationship between temporal and spatial variability of C2-C8 nonmethane hydrocarbon mixing ratios and their HO lifetimes (τ) is presented for samples collected during the 1993 North Atlantic Regional Experiment (NARE) and from other urban and ...
Blake, DR +7 more
core +2 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source