Results 101 to 110 of about 6,113,842 (346)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Perfil espacial e temporal de poluentes nas águas da represa municipal de São José do Rio Preto, São Paulo, Brasil Seasonal and spatial trend of pollutants in the waters of the São José do Rio Preto municipal dam, São Paulo state, Brazil

Química Nova, 2009
In this manuscript, seasonal and spatial trends of water collected from two sampling places in the Preto River in the Turvo-Grande watershed were evaluated.
Camila de Almeida Melo, Altair B. Moreira, Márcia Cristina Bisinoti   +2 more
doaj   +1 more source

Historical and modern trends of spatial development of Russia: social and demographic aspects

Наука. Культура. Общество, 2020
  The article is devoted to the consideration of the spatial development of Russia in historical retrospective and at the present stage. The paper analyzes the definitions of the term “spatial development”, considers the trends in territorial and ...
Vadim A. Bezverbny, Nikolay Yu. Mikryukov, Timur R. Miryazov   +2 more
doaj   +1 more source

An Analysis of Trends in Spatial Mobility of Dutch Graduates

Spatial Economic Analysis, 2011
Considerable attention in the literature has been devoted to spatial mobility as a mechanism in the transition from study to work. In this paper, the relationships between migration and both regional economic circumstances and individual characteristics are investigated using a micro-dataset on Dutch college and university graduates.
Venhorst, V.A., van Dijk, J., van Wissen, L.J.G.   +2 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Evaluating the Consistency of the 1982–1999 NDVI Trends in the Iberian Peninsula across Four Time-series Derived from the AVHRR Sensor: LTDR, GIMMS, FASIR, and PAL-II

Sensors, 2010
Successive efforts have processed the Advanced Very High Resolution Radiometer (AVHRR) sensor archive to produce Normalized Difference Vegetation Index (NDVI) datasets (i.e., PAL, FASIR, GIMMS, and LTDR) under different corrections and processing schemes.
José Paruelo, Javier Cabello, Siham Tabik, Elisa Liras, Domingo Alcaraz-Segura   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Analysis of spatial variability and temporal trends of rainfall in Amhara region, Ethiopia

Journal of Water and Climate Change, 2019
Understanding rainfall distribution in space and time is crucial for sustainable water resource management and agricultural productivity. This study investigated the spatial distribution and temporal trends of rainfall in Amhara region using time ...
M. Alemu, G. T. Bawoke
semanticscholar   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Rainy season precipitation trends over motloutse watershed in semi-arid eastern Botswana (1989–2019): implications on groundwater resources and sustainability

Geocarto International
This study examined trends in rainy season precipitation over the Motloutse Watershed using remotely sensed Climate Hazards Group Infrared Precipitation with Stations (CHIRPS-V2.0) data spanning the 1989/1990 to 2018/2019 hydrological years.
Gaolatlhe Bhutto Lentswe, Loago Molwalefhe   +1 more
doaj   +1 more source