Results 81 to 90 of about 6,113,842 (346)
Emerging trends and research frontiers in spatial multicriteria analysis
International Journal of Geographical Information Science, 2020 A majority of research on Spatial Multicriteria Analysis (SMCA) has been spatially implicit. Typically, SMCA uses conventional (aspatial) multicriteria methods for analysing and solving spatial problems.
J. Malczewski, P. Jankowski
semanticscholar +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Raumforschung und Raumordnung, 2009 The paper analyses two parallel, but distinct, trends of water management in Germany — the ecological orientation of water protection and the commercialisation of water services — in terms of their relevance for spatial development.
Timothy Moss
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Least squares estimation of nonlinear spatial trends
Computational Statistics & Data Analysis, 2010 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Rosa M. Crujeiras, Ingrid Van Keilegom
openaire +3 more sources
The Lancet, 2017 Summary Background Exposure to ambient air pollution increases morbidity and mortality, and is a leading contributor to global disease burden. We explored spatial and temporal trends in mortality and burden of disease attributable to ambient air ...
A. Cohen +29 more
semanticscholar +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Integrated, adaptive and participatory spatial planning: trends across Europe
, 2020 Whether spatial planning systems are equipped to cope with contemporary regional and urban challenges is strongly dependent on their capacity to promote integration between policy sectors, to respond adaptively to changing societal and political ...
V. Nadin +3 more
semanticscholar +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source