Results 151 to 160 of about 7,213,322 (346)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Spatial-temporal pattern of colorectal cancer mortality in a Northeastern Brazilian State.

PLoS ONE
Colorectal cancer (CRC) is one of the most common cancer types worldwide. Its increasing mortality trends, especially in emerging countries, are a concern.
Alex R Moura, Mayara E G Lopes, Mylena S Dantas, Adriane D Marques, Érika de A C Britto, Marcela S Lima, Hianga F F Siqueira, Ana C R Lisboa, Fernanda V S Moreira, Carlos A Lima   +9 more
doaj   +1 more source

OLS Estimator for a Mixed Regressive, Spatial Autoregressive Model: Extended Version [PDF]

We find the asymptotic distribution of the OLS estimator of the parameters $% \beta$ and $\rho$ in the mixed spatial model with exogenous regressors $% Y_n=X_n\beta+\rho W_nY_n+V_n$.
Mynbaev, Kairat
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Urban–Suburban PM_2.5 Trends in China Under Different Urban Classification Methods

Atmosphere
Urban–suburban PM2.5 differences are widely used to characterize spatial disparities in air pollution, yet their long-term trends may depend on urban definitions.
Ning Yang, Yuanwei Zhong, Fengjuan Fan, Guangjin Liu, Zonghan Xue, Yanru Bai, Nan Lu   +6 more
doaj   +1 more source

Temporal and spatial trends in road traffic fatalities from 2001 to 2019 in Shandong Province, China. [PDF]

PLoS One, 2023
Wang T, Yao ZY, Liu BP, Jia CX.
europepmc   +1 more source

Changing of the spatial development means and institution in hungary after the change of regime [PDF]

Before 1990, regional development policy as a governmental function was of secondary importance. Although economic planning, control and management were based on sectoral principles, regional processes contributed towards an equilibrium in the sense that
Krisztina Sóvágó, Valéria Jusztin
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Contextual factors and spatial trends of childhood malnutrition in Zambia. [PDF]

PLoS One, 2022
Phiri M, Mulemena D, Kalinda C, Odhiambo JN.   +3 more
europepmc   +1 more source