Results 91 to 100 of about 1,309,025 (309)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Sex Differences in Spatial Accuracy Relate to the Neural Activation of Antagonistic Muscles in Young Adults [PDF]

, 2017
Sex is an important physiological variable of behavior, but its effect on motor control remains poorly understood. Some evidence suggests that women exhibit greater variability during constant contractions and poorer accuracy during goal-directed tasks ...
Casamento-Moran, Agostina, Chen, Yen-Ting, Christou, Evangelos A., Fox, Emily J., Hunter, Sandra, Kwon, Min-Hyuk, Yacoubi, Basma   +6 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

How model and input uncertainty impact maize yield simulations in West Africa

Environmental Research Letters, 2015
Crop models are common tools for simulating crop yields and crop production in studies on food security and global change. Various uncertainties however exist, not only in the model design and model parameters, but also and maybe even more important in ...
Katharina Waha, Neil Huth, Peter Carberry, Enli Wang   +3 more
doaj   +1 more source

Hydrological controls on river network connectivity [PDF]

, 2019
This study proposes a probabilistic approach for the quantitative assessment of reach- and network-scale hydrological connectivity as dictated by river flow space–time variability. Spatial dynamics of daily streamflows are estimated based on climatic and
Botter, Gianluca, Celegon, Elisa Alessi, Fanton, Pietro, Garbin, Silvia   +3 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Reproduction of Twentieth Century Intradecadal to Multidecadal Surface Temperature Variability in Radiatively Forced Coupled Climate Models [PDF]

, 2012
[1] Coupled Model Intercomparison Project 3 simulations that included time-varying radiative forcings were ranked according to their ability to consistently reproduce twentieth century intradecadal to multidecadal (IMD) surface temperature variability at
Boer, Compo, Cordero, Crowley, DelSole, Eugene C. Cordero, Giorgi, Goosse, Hegerl, Hegerl, Jones, Karoly, Knutson, Kravtsov, Kunkel, Latif, Mann, Masiokas, Masson, Mauget, Mauget, Mauget, Meehl, Meehl, Mendenhall, Neelin, Ottera, Pan, Patrick T. Brown, Pierce, Rayner, Reichler, Robinson, Solomon, Steven A. Mauget, Swanson, Tebaldi, Tett, Wilks, Wu, Zhang   +40 more
core   +2 more sources

Research on the Spatial Variability of Soil Moisture [PDF]

, 2009
China is a country seriously suffering from the lack of water resource, especially the north of China (a dense area) where there are more agricultural production than other places in China. Therefore, some have become most important problems which should be settled down right now for precision agriculture: saving the water of agriculture, optimizing ...
Changli Zhang, Shuqiang Liu, Xianyue Zhang, Kezhu Tan   +3 more
openaire   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Exploring the variability and geographical patterns of population characteristics: Regional and spatial perspectives

Moravian Geographical Reports, 2017
The variability and geographical patterns of population characteristics are key topics in Human Geography. There are many approaches to exploring and quantitatively measuring this issue.
Netrdová Pavlína, Nosek Vojtěch
doaj   +1 more source