Results 81 to 90 of about 1,309,025 (309)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Spatial Variability of Grouting Layer of Shield Tunnel and Its Effect on Ground Settlement
Applied Sciences, 2020 This study aims to investigate the effect of the spatial variability of grouting-layer thickness on ground-surface settlement caused by shield tunneling and to provide a rational prediction method.
Zhongzheng Wang +2 more
doaj +1 more source
Interannual climate variability improves niche estimates for ectothermic but not endothermic species
Scientific Reports, 2023 Climate is an important limiting factor of species’ niches and it is therefore regularly included in ecological applications such as species distribution models (SDMs).
Dirk Nikolaus Karger +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Clustering and classifying images with local and global variability [PDF]
, 2009 A procedure for clustering and classifying images determined by three classification variables is presented. A measure of global variability based on the singular value decomposition of the image matrices, and two average measures of local variability
Giuliodori, Andrea +2 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Computational system for geostatistical analysis
Scientia Agricola, 2004 Geostatistics identifies the spatial structure of variables representing several phenomena and its use is becoming more intense in agricultural activities.
Laurimar Gonçalves Vendrusculo +3 more
doaj
Spatial variability of climate and past atmospheric circulation patterns from central West Antarctic glaciochemistry [PDF]
, 1999 Atmospheric circulation patterns and the spatial variability of atmospheric chemistry and moisture transport in central West Antarctica are investigated using new 40 year long (1954–1994 A.D.) glaciochemical and accumulation rate records developed from ...
Mayewski, Paul A. +4 more
core +3 more sources