Results 71 to 80 of about 1,309,025 (309)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Modelling within-region spatiotemporal variability in grapevine phenology with high resolution temperature data

OENO One, 2019
Aim: While it is well recognised that climate can vary spatially so that grapevine phenology significantly varies within a winegrowing region, the magnitude of temporal variability in climate determining factors to engender a significant difference in ...
Andrew Hall, John Blackman
doaj   +1 more source

Continental scale variability in ecosystem processes: Models, data, and the role of disturbance [PDF]

, 1997
Management of ecosystems at large regional or continental scales and determination of the vulnerability of ecosystems to large-scale changes in climate or atmospheric chemistry require understanding how ecosystem processes are governed at large spatial ...
Braswell, Rob, Schimel, David S
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Variability in the Precision of Children’s Spatial Working Memory

Journal of Intelligence, 2018
Cognitive modeling studies in adults have established that visual working memory (WM) capacity depends on the representational precision, as well as its variability from moment to moment.
Elena M. Galeano Weber, Judith Dirk, Florian Schmiedek   +2 more
doaj   +1 more source

Characterizing and Mitigating Sensor Generated Spatial Correlations in Airborne Hyperspectral Imaging Data

Remote Sensing, 2020
In hyperspectral imaging (HSI), the spatial contribution to each pixel is non-uniform and extends past the traditionally square spatial boundaries designated by the pixel resolution, resulting in sensor-generated blurring effects.
Deep Inamdar, Margaret Kalacska, George Leblanc, J. Pablo Arroyo-Mora   +3 more
doaj   +1 more source

Spatial Distribution of a Large Herbivore Community at Waterholes: An Assessment of Its Stability over Years in Hwange National Park, Zimbabwe. [PDF]

PLoS ONE, 2016
The spatial structuring of populations or communities is an important driver of their functioning and their influence on ecosystems. Identifying the (in)stability of the spatial structure of populations is a first step towards understanding the ...
Simon Chamaillé-Jammes, Anaïs Charbonnel, Stéphane Dray, Hillary Madzikanda, Hervé Fritz   +4 more
doaj   +1 more source

Spatial Interdependence and Instrumental Variable Models

Political Science Research and Methods, 2017
Instrumental variable (IV) methods are widely used to address endogeneity concerns in re- search using observational data. Yet, a specific kind of endogeneity – spatial interdependence – is regularly ignored in this research, threatening claims of causal identification.
Betz, Timm, Hollenbach, Florian, Cook, Scott   +2 more
openaire   +3 more sources

Spatial Correlation Variability in Multiuser Systems [PDF]

2018 IEEE International Conference on Communications (ICC), 2018
Spatial correlation across an antenna array is known to be detrimental to the terminal signal-to- interference-plus-noise-ratio (SINR) and system spectral efficiency. For a downlink multiuser multiple-input multiple-output system (MU-MIMO), we show that the widely used, yet overly simplified, correlation models which generate fixed correlation patterns
Harsh Tataria, Peter J. Smith 0001, Andreas F. Molisch, Seun Sangodoyin, Michail Matthaiou, Pawel A. Dmochowski, Jianzhong Zhang 0002, Reiner S. Thomä   +7 more
openaire   +3 more sources