Results 111 to 120 of about 1,203,505 (306)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Spatio-temporal analysis reveals active control of both task-relevant and task-irrelevant variables
Frontiers in Computational Neuroscience, 2013 The Uncontrolled Manifold hypothesis and Minimal Intervention principle propose that the observed differential variability across task relevant (i.e., task goals) vs.
Kornelius eRácz +1 more
doaj +1 more source
GEOGRAPHIC AND INSTITUTIONAL DETERMINANTS OF REAL INCOME:A SPATIO-TEMPORAL SIMULTANEOUS EQUATION APPROACH [PDF]
This paper tests a series of prominent hypotheses regarding the determinants of per-capita income using a novel spatial econometric approach to control for spillovers among neighboring countries and for spatially correlated omitted variables.
Guyslain K. Ngeleza +2 more
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Reversible, Selective, Ultrawide‐Range Variable Stiffness Control by Spatial Micro‐Water Molecule Manipulation (Adv. Sci. 20/2021) [PDF]
, 2021 Inho Ha +9 more
openalex +1 more source
The determinants of urban density: the Israeli case [PDF]
In the struggle against urban sprawl minimum requirements for urban density has become one of the promising tools in determining spatial planning policy, particularly in densely populated countries. This tool was first proposed in the Israel Master Plan '
Frenkel, Amnon
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Geostatistical indexes for quantifying spatial information on hyperspectral imaging: an application for the evaluation of regression models [PDF]
, 2019 Hyperspectral (HS) images have the characteristic of containing both spectral and spatial information of a sample. Typically, spectral information can be related with chemical and physical properties through multivariate regression models.
Chaix, Gilles +6 more
core
FEBS Open Bio, EarlyView.IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić +3 more
wiley +1 more source