Results 61 to 70 of about 600,167 (284)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The dynamics of disordered dialogue: Prefrontal, hippocampal and thalamic miscommunication underlying working memory deficits in schizophrenia

Brain and Neuroscience Advances, 2018
The prefrontal cortex is central to the orchestrated brain network communication that gives rise to working memory and other cognitive functions. Accordingly, working memory deficits in schizophrenia are increasingly thought to derive from prefrontal ...
David A Kupferschmidt, Joshua A Gordon
doaj   +1 more source

Working memory load elicits attentional bias to threat [PDF]

, 2014
Anxious individuals tend to show attentional bias to threats and dangers; this is usually in-terpreted as a specific bias in threat-processing. However, they also tend to show general working memory and cognitive control impairments. We hypothesised that
Booth, Robert, Sharma, Dinkar
core  

Relationship between spatial ability, visuospatial working memory and self-assessed spatial orientation ability: a study in older adults [PDF]

, 2015
This paper describes some novel spatial tasks and questionnaires designed to assess spatial and orientation abilities. The new tasks and questionnaires were administered to a sample of 90 older adults (41 males, age range 57–90), along with some other ...
A Bordin, Annalena Venneri, AS Devlin, B Milner, Bandura, C Cornoldi, CA Lawton, CA Lawton, D Voyer, DF Lohman, DH Uttal, DR Montello, E Borella, E Coluccia, E Labate, E Renzi De, EA Maguire, F Bianchini, F Pazzaglia, F Pazzaglia, F Pazzaglia, F Pazzaglia, F Pazzaglia, F Pazzaglia, Francesca Pazzaglia, G Iaria, GK Aguirre, GL Allen, GW Evans, I Viaud-Delmon, IC Mammarella, IC Mammarella, J Eliot, J Kallai, JB Carroll, K Jöreskog, KC Kirasic, KJ Bryant, KJ Bryant, KW Schaie, L Piccardi, LT Kozlowski, Lucia Ronconi, M Denis, M Hegarty, M Hegarty, M Hegarty, M Mitolo, MA Bell, MC Linn, ME Lachman, MG McGee, Micaela Mitolo, NBM Quental, NM White, P Oltman, Paolo Caffarra, R Likert, R Nori, R Nori, RB Ekstrom, S Della Sala, SG Vandenberg, Simona Gardini, T Hartley, T Wolbers, TM Sgaramella, V Ross   +67 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

No role of working memory in the relation between mental rotation and postural stability

Frontiers in Cognition
This study investigated the relationship between mental rotation ability and postural stability, with a focus on the role of the visuospatial sketchpad of working memory, as it has been found to be correlated with both concepts.
Philipp Hofmann, Markus Siebertz, Petra Jansen   +2 more
doaj   +1 more source

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

The Unique Role of Spatial Working Memory for Mathematics Performance

Journal of Numerical Cognition, 2022
We explored the multi-dimensionality of mathematics and working memory (WM) by examining the differential relationships between different areas of mathematics with visual, spatial, and verbal WM.
Sarit Silverman, Sarit Ashkenazi
doaj   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Is Working Memory Necessary for Both Selection and Calculation in Level 1 Visual Perspective Taking? Evidence from Children and Adults

Behavioral Sciences
Previous research has suggested that there are two modular processes of perspective selection and calculation in level 1 perspective taking. Evidence further showed that verbal working memory is associated with both processes in adults. However, research
Guifen He, Wei Song, Peiqi Dong, Canmei Xu, Yanlin Zhou, Haoqin Ye, Qiong Zhang   +6 more
doaj   +1 more source