Results 61 to 70 of about 8,055,585 (338)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Alpha-band activity reveals spontaneous representations of spatial position in visual working memory
Current Biology, 2017 Summary An emerging view suggests that spatial position is an integral component of working memory (WM), such that non-spatial features are bound to locations regardless of whether space is relevant [1,2].
Joshua J. Foster +3 more
semanticscholar +1 more source
Spatial working memory deficit in unilateral neglect
Neuropsychologia, 2001 Based on the similarity of brain areas lesioned in neglect and those activated by spatial working memory (WM) tasks in normals, we hypothesized that neglect may involve spatial WM impairments. A left neglect patient with right inferior frontal and basal ganglia damage performed cancellation tasks, making either highly visible marks (to provide a ...
Wojciulik, E +3 more
openaire +4 more sources
Spatial Inferences in Narrative Comprehension: the Role of Verbal and Spatial Working Memory [PDF]
, 2016 During the comprehension of narrative texts, readers keep a mental representation of the location of protagonists and objects; a breach in spatial coherence is detected by longer online reading times (consistency effect).
Irrazabal, Natalia Carolina +1 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Journal of Bio-X Research, 2022 . Objective:. Only a few studies have investigated the development trends in spatial working memory and attention among a large sample of primary school students over a wide range of ages, while the efficiency of learning and memory processes is ...
Nengpeng Zhan +13 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Reward Expectation Differentially Modulates Global and Local Spatial Working Memory Accuracy
Frontiers in Psychology, 2021 Although it has been suggested that reward expectation affects the performance of spatial working memory tasks, controversial results have been found in previous experiments.
Qingjie Zhou, Zanzan Jiang, Jinhong Ding
doaj +1 more source
eLife, 2016 Several lines of evidence suggest that the striatum has an important role in spatial working memory. The neural dynamics in the striatum have been described in tasks with short delay periods (1–4 s), but remain largely uncharacterized for tasks with ...
H. Akhlaghpour +5 more
semanticscholar +1 more source
Geometry of sequence working memory in macaque prefrontal cortex
Science, 2022 How the brain stores a sequence in memory remains largely unknown. We investigated the neural code underlying sequence working memory using two-photon calcium imaging to record thousands of neurons in the prefrontal cortex of macaque monkeys memorizing ...
Yang Xie +10 more
semanticscholar +1 more source