Results 101 to 110 of about 14,742 (315)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Roofscapes and the spatiality of the common [PDF]
, 2012 The relationship between forms of delimitation and expropriation of the commons through the management of the "public" have led to a world of enclosures and exact division lines. But this is not how the individual perceives and experiences space, this is
García de Jalón Oyarzun, Lucía
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Vocalic space: socio-materiality and sonic spatiality
, 2017 This chapter looks at the ways in which social and cultural theory might provide a set of resources for theorising sonic spatiality. This is worked through the specific example of the spatiality of voice conceptualised through Steven Connor’s (2000 ...
Revill, George
core
Mediating the Spatiality of Conflicts: International Conference Proceedings
, 2020 Conflict, when dislodged from its conventional understanding as a process and system of war and destruction exclusively, may be apprehended as an experimental method for analysis and synthesis, as a potent resource for pedagogy, for disruptive design and
Undetermined, U. (author)
core
Spatiality and Teacher Workplace Cultures [PDF]
, 2004 Space makes a difference. Although much schooling is spatially constituted, its significance is largely unrecognised in educational research. In this thesis I explore how space is implicated in the construction of the school as a workplace for teachers ...
McGregor, Jane Hazel
core +1 more source
Cultures et politiques dans les Alpes contemporaines
Revue de Géographie Alpine, 2008 More than ever before, the Alps are affected by increasingly varied and powerful flows and equally by the multiplication of initiatives designed to strengthen or regenerate the idea of “locality” (place).
Bernard Debarbieux
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Exploring the Timescape of Urban Camping Activities: A Case Study of Guangzhou
Redai diliIn the post-pandemic period, urban camping has become a popular form of leisure in China. Such urban camping activities, which were originally "anti-everydayness", have infiltrated urban living spaces, forming an urban leisure landscape that differs from
Huang Yuhang, Liu Chen
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source