Results 61 to 70 of about 7,519 (215)

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells

open access: yesAdvanced Science, EarlyView.
A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin   +6 more
wiley   +1 more source

Temporal Modulation of the Control Parameter in Electroconvection in the Nematic Liquid Crystal I52

open access: yes, 2000
I report on the effects of a periodic modulation of the control parameter on electroconvection in the nematic liquid crystal I52. Without modulation, the primary bifurcation from the uniform state is a direct transition to a state of spatiotemporal chaos.
D. Walgraef   +24 more
core   +1 more source

Optical injection locking and optical-fiber data transmission by directly modulated wavelength tunable laser transmitters

open access: yesAIP Advances
Enhancement of the small- and large-signal modulation performance of wavelength tunable laser diode (TLD) transmitters under strong optical injection locking (OIL) is investigated numerically in back-to-back and optical-fiber transmission schemes.
N. Zakhleniuk, O. Duzgol
doaj   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

open access: yesAdvanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang   +7 more
wiley   +1 more source

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

open access: yesAngewandte Chemie, EarlyView.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +2 more sources

Transverse Patterns in Nonlinear Optical Resonators

open access: yes, 2003
The book is devoted to the formation and dynamics of localized structures (vortices, solitons) and extended patterns (stripes, hexagons, tilted waves) in nonlinear optical resonators such as lasers, optical parametric oscillators, and photorefractive ...
Sanchez-Morcillo, Victor J.   +1 more
core   +1 more source

All-fiber spatiotemporally mode-locked laser with multimode fiber-based filtering

open access: yesOptics Express, 2020
We demonstrate the first all-fiber multimode spatiotemporally mode-locked laser. The oscillator generates dissipative soliton pulses at 1036 nm with 12 mW average power, 6.24 ps duration, and 24.3 MHz repetition rate. The reported pulse energy (0.5 nJ) represents ∼4 times improvement over the previously reported single-mode all-normal dispersion mode ...
Uğur Teğin   +4 more
openaire   +3 more sources

Precision‐Engineered Silver Single‐Atom Carbon Dot Nanozymes for Theranostic Management of Acute Kidney Injury

open access: yesAdvanced Science, EarlyView.
Mitochondria‐targeted silver single‐atom carbon dot (T‐AgSA‐CDs) nanozymes enable dual SOD/GPx‐like ROS scavenging, real‐time imaging, and therapeutic effects for acute kidney injury (AKI). Atomically dispersed Ag sites synergize with carbon dots to restore renal redox hemostasis, protect mitochondrial function, mitigate inflammation, facilitate post ...
Tianle Tang   +10 more
wiley   +1 more source

Self-synchronization of Kerr-nonlinear Optical Parametric Oscillators [PDF]

open access: yes, 2016
We introduce a new, reduced nonlinear oscillator model governing the spontaneous creation of sharp pulses in a damped, driven, cubic nonlinear Schroedinger equation.
Adibi, Ali   +4 more
core   +2 more sources

Phase reduction approach to synchronization of spatiotemporal rhythms in reaction-diffusion systems

open access: yes, 2014
Reaction-diffusion systems can describe a wide class of rhythmic spatiotemporal patterns observed in chemical and biological systems, such as circulating pulses on a ring, oscillating spots, target waves, and rotating spirals. These rhythmic dynamics can
Kawamura, Yoji   +2 more
core   +2 more sources

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