Results 51 to 60 of about 421,690 (259)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Evaluation of the Vulnerability of Speaker Verification to Synthetic Speech [PDF]
, 2010 In this paper, we evaluate the vulnerability of a speaker verification (SV) system to synthetic speech. Although this problem was first examined over a decade ago, dramatic improvements in both SV and speech synthesis have renewed interest in this ...
Pucher, M. +4 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
To What Extent Does Incorrect Pronunciation Alter Meaning
Altralang Journal, 2019 This article targets a feature of the language which is essential in foreign language acquisition. All the skills are important to acquire when we are learning a foreign or a second language.
Zoubida SEBANE
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Experiences and perceptions of nonnative-speaker teacher trainees on a TESOL programme in New Zealand [PDF]
, 2009 This paper reports research which focussed on a group of non-native speakers of English who had completed an entry-level TESOL (Teaching English to Speakers of Other Languages) qualification in a tertiary institution in New Zealand.
Edwards, Susan
core +1 more source
How to Build a Local Brand Through Local Sustainability
Acta Economica et Turistica, 2017 In this paper it will be shown how to build a local brand through the model of local sustainability. Territorial assets as a local activity and informal rules for a joint work of a community are taken as starting points in brand creation.
Dončić Siniša Hajdaš, Đurek Nikola
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Speaker-Independent Speech Enhancement with Brain Signals
, 2021 Single-channel speech enhancement algorithms have seen great improvements over the past few years. Despite these improvements, they still lack the efficiency of the auditory system in extracting attended auditory information in the presence of competing ...
Maryam Hosseini (11437267) +2 more
core +1 more source