Results 11 to 20 of about 4,781,571 (231)

Correlation between machining direction, cutter geometry and step-over distance in 3-axis milling: Application to milling by zones. [PDF]

, 2012
Computer-Aided Manufacturing (CAM) occupies an increasingly important role in engineering with all it has to offer in terms of new possibilities and improving designer/manufacturer productivity. The present study addresses machining of free-form surfaces
Senatore, Johanna, Rubio, Walter, Segonds, Stéphane, Dessein, Gilles   +3 more
core   +1 more source

Evidence‐Based Clinical Practice Guidelines for the Management of Pediatric Febrile Neutropenia: Resource‐Sensitive Recommendations for the Asian Continent

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes.
Joliza Patricia Cañeba, Shweta Bansal, Tea Reljic, Allyne Montecillo‐Aguelo, Hamidah Alias, Farrah Amaranto, Maria Stella Aquino‐Calingasan, Bambang Ardianto, Eggi Arguni, Sally Blair, Thi Tam Dang, Maria Beatriz Gepte, Samanmalee Gunasekara, Andini Handayani, Miriam Kimpo, Catherine G. Lam, Nawachai Lertvivatpong, Sergio Licona, Ana Loseo, Ratha Mlis, Vivian Moreno Berrio, Nguyen Hoai Anh, Anna Lisa Ong‐Lim, Ha Thu Pham, Krishna Sagar Sharma, Bun Sereyleak, Sally Jane G. Velasco‐Aro, Su Yadana, Ambuj Kumar, Sheena Mukkada   +29 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Study on Cutting Force of Diamond Cutter in Special-Shaped Stone Processing

, 2011
The cutting force is the key factors influencing the processing precision and efficiency in special-shaped stone production. In this research, the cutting force is measured and analyzed in the process of special shaped cutter cutting stone.
Bo Huang, Zeng Wen Liu
core   +1 more source

Calculation of the producing surfaces of milling cutters for processing gears of eccentric-cycloidal engagement [PDF]

E3S Web of Conferences
The paper considers a new method for processing curved gears of eccentric-cycloidal engagement with a curved profile using a special tool. The surfaces of wheels of eccentric-cycloidal engagement with a curved profile for small and large wheels are ...
Kuts Vadim, Malneva Julia
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Mechanical properties and rock-breaking effects of ridge-shaped PDC teeth

Jin'gangshi yu moliao moju gongcheng
Objectives: With the depletion of easily recoverable oil reservoirs, the focus of oil and gas exploration and development in China has shifted to "two deeps and non-conventional" oil and gas fields.
Zhitao XIE, Yuxuan ZHAO, Yong GUO, Desheng WU, Yadong LI   +4 more
doaj   +3 more sources

MODELING OF A DUPLEX MILLER AND CONDITIONS OF FORMATION OF TREATMENT OF WHEEL PAIRS OF MAIN ELECTRIC CARDS, DUAL CARS, ELECTRO SECTIONS

Сучасний стан наукових досліджень та технологій в промисловості, 2019
The subject matter of the research in the article is the process of restoring the quality and accuracy of the working surface of the wheelsets of the main electric locomotives, electric sections.
Victor Shapovalov, Alexandr Permyakov, Alexander Klochko   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source