Results 21 to 30 of about 43,494 (242)

Multi-step self-guided pathways for shape-changing metamaterials [PDF]

, 2018
Multi-step pathways, constituted of a sequence of reconfigurations, are central to a wide variety of natural and man-made systems. Such pathways autonomously execute in self-guided processes such as protein folding and self-assembly, but require external
Alberico Sabbadini, B Wei, C Coulais, C Coulais, C Coulais, C Coulais, C Coulais, CM Dobson, Corentin Coulais, D Mousanezhad, E Winfree, Fré Vink, J Rogers, JN Grima, JT Overvelde, JT Overvelde, K Bertoldi, K Bertoldi, M Stern, Martin van Hecke, MB Pinson, MK Blees, Q Chen, R Gatt, RF Shepherd, S Felton, S Waitukaitis, S Xu, SD Huber, T Mullin, V Zykov, Y Cho, Y Tang, Y Zhang, Z Zeravcic   +34 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Key Drilling Technologies for Ultra-Deep Well Zheng 10 in Junggar Basin

Shiyou jixie, 2023
The strata below the Qingshuihe Formation in the Junggar Basin are found with high uncertainty,low drillability and complicated pressure system,which severely restrains the progress of exploration and development by deep exploration wells in the lower ...
Sun Jiaxiang, Zhao Hongshan, Ma Li
doaj  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Experimental Study on Rock Breaking Effect of Axe-Shaped and Triangular-Ridged Cutters Under Impact Load

Shiyou jixie
In drilling engineering， optimized cutter selection for specific formations is critical to enhance rock breaking efficiency. To this end， a Split Hopkinson Pressure Bar （SHPB） apparatus was used to conduct impact-induced rock breaking tests of triangular-
Li Yunzhu, Liu Ronghe, Du Jianhong, Liu Bin, Wang Wenwen, XI Yan, Zhang Tianze   +6 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Race and Income Disparities in Disaster Preparedness in Old Age [PDF]

, 2017
Objective: Older adults are one of the most vulnerable populations impacted by disasters and communities continue to struggle addressing preparedness.
Cox, Katherine M.
core   +1 more source

Reasons and Theories of Sensory Affect [PDF]

, 2018
Some sensory experiences are pleasant, some unpleasant. This is a truism. But understanding what makes these experiences pleasant and unpleasant is not an easy job. Various difficulties and puzzles arise as soon as we start theorizing.
Aydede, Murat, Fulkerson, Matthew
core   +1 more source