Results 111 to 120 of about 896,807 (281)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Interview with Salvatore Ciolino, July 9, 2002
, 2002 Salvatore Ciolino was interviewed on July 9, 2002 by Michael Birkner about his time at Gettysburg College when Charles Glassick was president. He discussed his position as director of Financial Aid during the 1970\u27s-1980\u27s.
Birkner, Michael J., Ciolino, Salvatore
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Interview with Marion Ecker, June 23, 2001
, 2001 Marion Ecker was interviewed on June 23, 2001 by Michael J. Birkner about her life as a resident of Adams County. Ecker discusses her childhood and education at Shippensburg State, as well as her teaching career in Gettysburg.
Birkner, Michael J., Ecker, Marion
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Interview with Arthur Bruce Boenau, June 9, 2005
, 2005 Arthur Bruce Boenau was interviewed on June 9, 2005 by Michael Birkner about his life and time as a professor of Political Science at Gettysburg College.
Birkner, Michael J. +1 more
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NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Interview with Robert Reynolds, August 23, 2000
, 2000 In the last part of a series of interviews conducted by Michael J. Birkner, Robert Reynolds discussed on August 23, 2000 his life after World War II. After the war, Reynolds moved to Gettysburg.
Birkner, Michael J., Reynolds, Robert
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source