Results 91 to 100 of about 896,807 (281)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Classification of Digital Emergence: A Critical Approach to the Production of Digital Objects in Special Collections

Canadian Journal of Academic Librarianship, 2016
This paper examines the infrastructure of digital libraries and teases out the subtle ways their formation and construction is a digital extension and representation of the social, political, and institutional circumstances by which they are created ...
Robert D. Montoya
doaj   +1 more source

Pohanka Reflection: Special Collections & Archives, Musselman Library, Gettysburg College

, 2014
The reading room of Gettysburg College’s Special Collections is one of those singular spaces where the denizens of academe encounter the uninitiated yet insatiably curious members of that nebulous group known as the public. Indeed, many summer afternoons
Caswell, Bryan G.
core  

Using Google Analytics, Voyant and Other Tools to Better Understand Use of Manuscript Collections at L. Tom Perry Special Collections [PDF]

, 2017
[Excerpt] Developing strategies for making data-driven, objective decisions for digitization and value-added processing. based on patron usage has been an important effort in the L. Tom Perry Special Collections (hereafter Perry Special Collections).
Daines, J. Gordon, III, Lee, Ryan K, Nimer, Cory L, Rupp, Shelise   +3 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Integrating Premodern Manuscript Metadata into Wikidata: A Case Study in Ontology Design and Linked Data Reuse

Journal of Open Humanities Data
This article presents Digital Scriptorium’s efforts to model and integrate premodern manuscript metadata into Wikidata, addressing challenges posed by inconsistent cataloging practices and the limitations of existing data models.
Rose A. McCandless, L. P. Coladangelo
doaj   +1 more source

Academic Special Collections and the Myths of Copyright

Journal of Copyright in Education and Librarianship, 2019
This study compares the copyright and use policy statements posted on the websites of the special collections of Association of Research Libraries member libraries.
Teresa Auch Schultz, Dana Miller
doaj   +1 more source

Editorial: Covid-19 special collection

African Journal of Primary Health Care & Family Medicine, 2020
No abstract available.
openaire   +5 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source