Results 71 to 80 of about 12,191,620 (284)
Scientific ReportsAssessing the suitability of unconditioned buildings for adaptive reuse as archival storages, particularly with respect to their microclimate behaviour, remains a complex and evolving methodological challenge.
Giulia Boccacci +5 more
doaj +1 more source
Introduction to the Rosetta Special Collection
PLOS ONE, 2015 The Rosetta macromolecular modeling software is a versatile, rapidly developing set of tools that are now being routinely utilized to address state-of-the-art research challenges in academia and industrial research settings. A Rosetta Conference (RosettaCon) describing updates to the Rosetta source code is held annually.
Sagar D Khare, Timothy A Whitehead
openaire +4 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
UNLV Special Collections in the Twenty-First Century
Information Technology and Libraries, 2009 University of Nevada Las Vegas (UNLV) Special Collections is consistently striving to provide several avenues of discovery to its diverse range of patrons.
Thomas Sommer
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Manuscript Collections, Archives, and Special Collections
Library & Archival Security, 1984 Toutes ces collections sont generalement rassemblees sous une administration specialisee en livres rares. Cette approche qui s'etend aux manuscrits est depassee pour les fonds modernes de manuscrits, les techniques actuelles exigent une autonomie pour ces fonds.
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Notice_on_Potentially_Offensive_Historical_Language_and_Content_FINAL
Archives and Special Collections statement of potentially offensive or harmful historical language and/or ...
Archives and Special Collections
core +1 more source