Results 61 to 70 of about 896,807 (281)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Special Collections

open access: yesCollege & Research Libraries, 1963
Made available in DSpace on 2013-01-29T18:19:20Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) crl_24_02_113_opt.pdf: 1759423 bytes, checksum: cec8f9cd399f981b86a5acd0159c8fcc (MD5) Previous issue date: 1963-03 ; published or submitted for ...
openaire   +2 more sources

Special Collections Roadshow — Episode Seven: Housewife

open access: yes, 2016
Special Collections Roadshow was created by the Civil War Institute at Gettysburg College in the Spring of 2014. It showcases various artifacts from Special Collections at Gettysburg College.
McNish, Megan E., Sutter, Meg A.
core  

Closing the Loop: Creating Deliverables That Add Value [PDF]

open access: yes, 2016
As special collections librarians and liaison librarians work together to create in­novative experiences working with primary source material, it is important to remember students have much to offer in the collaborative design process. In this case study,
DeSanto, Daniel L., Doherty, Prudence J.
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Data dreams: planning for the future of historical medical documents

open access: yesJournal of the Medical Library Association, 2018
Historical medical collections with privacy-sensitive information are a potentially rich source of social, behavioral, and economic data for a wide array of researchers.
Lorraine Dong   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Faces of the Civil War [PDF]

open access: yes, 2015
As the internship enters its final month of the summer, I’ve been processing and looking at various Civil War collections. This era in history is well known for the bloody conflicts that separated the nation.
Semmel, Steven J.
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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