Results 81 to 90 of about 16,612,164 (345)

The humanitarian, development and peace nexus (HDPN) in Africa: the urgent need for a coherent framework for health

open access: yesBMJ Global Health, 2023
Sohel Saikat   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Some fundamental Fibonacci number congruences [PDF]

open access: yesNotes on Number Theory and Discrete Mathematics
This paper investigates a number of congruence properties related to the coefficients of a generalized Fibonacci polynomial. This polynomial was defined to produce properties comparable with those of the standard polynomials of some special functions ...
Anthony G. Shannon   +3 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The Generalized Fox–Wright Function: The Laplace Transform, the Erdélyi–Kober Fractional Integral and Its Role in Fractional Calculus

open access: yesMathematics
In this paper, we consider and study in detail the generalized Fox–Wright function Ψ˜qp introduced in our recent work as an extension of the Fox–Wright function Ψqp.
Jordanka Paneva-Konovska   +1 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Semi-Automatic Floating-Point Implementation of Special Functions

open access: yesIEEE Symposium on Computer Arithmetic, 2015
This work introduces an approach to the computer-assisted implementation of mathematical functions geared toward special functions such as those occurring in mathematical physics.
C. Lauter, M. Mezzarobba
semanticscholar   +1 more source

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