Results 131 to 140 of about 338,989 (310)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

A Simple Deformation of Special Relativity [PDF]

open access: yesarXiv, 2003
A deformation of special relativity based on a dispersion relation with an energy independent speed of light and a symmetry between positive and negative energy states is proposed. The deformed Lorentz transformations, generators and algebra are derived and some consequences are discussed.
arxiv  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Doubly Special Relativity and quantum gravity phenomenology [PDF]

open access: yesarXiv, 2003
I review the conceptual, algebraical, and geometrical structure of Doubly Special Relativity. I also speculate about the possible relevance of DSR for quantum gravity phenomenology.
arxiv  

Germline variants in CDKN2A wild‐type melanoma prone families

open access: yesMolecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen   +5 more
wiley   +1 more source

A new spin on special relativity. [PDF]

open access: yesScience, 2020
Daniels MW, Stiles MD.
europepmc   +1 more source

The experimental status of Special and General Relativity [PDF]

open access: yesarXiv, 2012
In this contribution we assess the current experimental status of Special and General Relativity. Particular emphasis is put on putative extensions of these theories and on how these could be detected experimentally.
arxiv  

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