Results 31 to 40 of about 697,557 (339)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Expanding horizons: lung transplantation for non-IPF interstitial lung diseases

BMC Pulmonary Medicine
Objective Interstitial lung diseases (ILDs) are diverse pulmonary disorders marked by diffuse lung inflammation and fibrosis. The variability in characteristics and treatment approaches complicates diagnosis and management.
Sevinc Citak, Ertan Saribas, Ayse Nigar Halis, Fatma Feyza Alkilic, Murat Ersin Cardak, Mustafa Vayvada, Ahmet Erdal Tasci   +6 more
doaj   +1 more source

Transhistorical views over journalism as a profession [PDF]

Social Sciences and Education Research Review, 2017
In this paper we aim to describe the basics, the roots, the genetic heritage of the today Romanian journalism, as a profession and epistemic object. The idea came to us from this need to offer an answer, an explanation regarding the necessity of a strong
Xenia Negrea, Dan Valeriu Voinea
doaj  

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

(WP 2018-05) Specialization, Fragmentation, and Pluralism in Economics [PDF]

, 2018
This paper investigates whether specialization in research is causing economics to become an increasingly fragmented and diverse discipline with a continually rising number of niche-based research programs and a declining role for dominant cross-science ...
Davis, John B.
core   +1 more source

Late-onset Sheehan’s syndrome: a major diagnostic challenge—a case report

Journal of Medical Case Reports
Background Sheehan’s syndrome is a form of maternal hypopituitarism resulting from excessive blood loss during or after childbirth. This extensive bleeding may reduce blood flow to the pituitary gland, causing pituitary cell damage and death (necrosis ...
Luis Miguel Osorio-Toro, Yessica Alejandra Ordoñez-Guzman, Jhon Fernando Montenegro-Palacios, Jhon Herney Quintana-Ospina, Julian Andres Pacichana-Abadia, Jorge Enrique Daza-Arana, Hector Fabio Escobar-Vargas, Katherine Restrepo-Erazo, Andrés Felipe García-Ramos   +8 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Efficacy of transbronchial biopsy and frequency of pneumothorax in lung transplant recipients: single center experience

BMC Pulmonary Medicine
Objective Bronchoscopy plays a critical role in the diagnosis and management of lung transplant recipients. We retrospectively evaluated the safety, complications, and efficacy of transbronchial biopsy (TBB) in detecting and grading early rejection ...
Ertan Sarıbaş, Ayse Nigar Halis, Sevinç Çıtak, Gonca Gecmen, Ahmet Murat Kazan, Musatafa Vayvada, Murat Ersin Cardak, Ahmet Erdal Taşçı   +7 more
doaj   +1 more source

Optimal setting and care organization in the management of older adults with hip fracture: a narrative review

Geriatric Care, 2015
Hip fracture (HF) is a common event in older adults and is associated with significant morbidity, mortality, reduction of quality of life and costs for the healthcare systems.
Andrea Giusti, Antonella Barone, Monica Razzano, Rita Raiteri, Andrea Del Rio, Viviana Bassoli, Ernesto Palummeri, Mauro Oliveri, Alberto Pilotto   +8 more
doaj   +1 more source