Results 91 to 100 of about 886,303 (268)

Use of contraception during first sexual intercourse among Norwegian adolescents: a national cross-sectional study

open access: yesBMC Public Health
Background Most Norwegian adolescents experience their first sexual intercourse during late adolescence. Use of contraception is important to avoid unwanted pregnancy, while condoms can also protect against sexually transmitted diseases.
Live Solveig Nordhagen   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

SPECIAL IS AS SPECIAL DOES

open access: yesRBM: A Journal of Rare Books, Manuscripts, and Cultural Heritage, 2000
Nothing is very special in the least about special collections unless they are made meaningful. The meaning derives from the interaction of the artifact and the individual mind and heart; Rachel Howarth, in a companion piece to this one, has provided many examples of such encounters.
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

To specialize or too specialized?

open access: yesCanadian Medical Education Journal, 2013
In January of 2011 I, together with my fourth-year medical student colleagues, returned to the University of Western Ontario from our electives to begin four months of preparation for our medical licensing exam. During large group discussions on general clinical scenarios, it was clear that, for most students, specialization was well underway.
openaire   +4 more sources

Early‐Phase Research in Pediatric Neuro‐Oncology

open access: yes
Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Pharmacogenetic aspects of eprosartan therapy and polymorphic markers of renin-angiotensin-aldosterone system genes in Uzbek patients with essential arterial hypertension

open access: yesКардиоваскулярная терапия и профилактика, 2009
Aim. To investigate antihypertensive and anti-remodeling effects of eprosartan in Uzbek patients with essential arterial hypertension (AH), taking into consideration renin-angiotensin-aldosterone system genetic polymorphism.Material and methods.
D. R. Kurbanova   +3 more
doaj  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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