Results 101 to 110 of about 1,492,701 (311)

EFFICACY OF ROSUVASTATIN IN DYSLIPIDEMIA CORRECTION IN PATIENTS AFTER Q-WAVE MYOCARDIAL INFARCTION

Рациональная фармакотерапия в кардиологии, 2015
Aim. To study the efficacy of rosuvastatin in dyslipidemia correction in patients after Q-wave myocardial infarction (Q-MI).Material and methods. 40 patients (aged 52.7±9.4 years old) were included into the study after 10-14 days of the acute Q-MI onset.
R. D. Kurbanov, N. U. Zakirov, Y. G. Kevorkova, N. B. Sayfiddinova   +3 more
doaj   +1 more source

SPECIAL IS AS SPECIAL DOES

RBM: A Journal of Rare Books, Manuscripts, and Cultural Heritage, 2000
Nothing is very special in the least about special collections unless they are made meaningful. The meaning derives from the interaction of the artifact and the individual mind and heart; Rachel Howarth, in a companion piece to this one, has provided many examples of such encounters.
openaire   +2 more sources

Sub-specialization or Super-specialization in Surgery? [PDF]

BMJ, 1970
A special centre for prosthetic hip replacement set up 10 years ago has been successful in its primary objectives, producing high quality work at low cost and stimulating research. The project has not yet been successful in achieving a permanent staffing structure, but this is the effect of certain British ideologies in surgical training, with the ...
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Phylogeny of the specialized schizothoracine fishes (Teleostei : Cypriniformes : Cyprinidae)

, 2001
Phylogeny of the specialized schizothoracine fishes (Teleostei: Cypriniformes: Cyprinidae). Zoological Studies 40(2). 147-157. To elucidate phylogenetic relationships within the specialized schizothoracine fishes, we used 41 variable osteological and ...
Jian Yang & Xiaoyong Chen & Junxing Yang, Chen, YF, Chinese Acad Sci, Inst Hydrobiol, Hubei 430072, Peoples R China   +1 more
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Towards collaborative journalism in Specialized Communication

This chapter examines specialized communication within the field of jour-nalism, focusing on the discursive practices journalists use to interact with and makesense of news in highly specialized fields – such as science, politics, and the arts – toboth ...
Jacobs, GeertLW068010016449160000-0003-1180-0487F6782680-F0ED-11E1-A9DE-61C894A0A6B4, Roelcke, Thorsteneditor, Breeze, Rutheditor, Verkest, SofieLW060000604631308020006500370000-0001-6544-84880C0B9F72-F0EE-11E1-A9DE-61C894A0A6B4, Engberg, Janeditor   +4 more
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Root-exuded specialized metabolites reduce arsenic toxicity in maize. [PDF]

By releasing specialized metabolites, plants modify their environment. Whether and how specialized metabolites protect plants against toxic levels of trace elements is not well understood.
Mateo, Pierre, Erb, Matthias, Robert, Christelle A M, Wälchli, Jan, Robert, Christelle A. M., Bigalke, Moritz, Schlaeppi, Klaus, Deslandes-Hérold, Gabriel, Spielvogel, Sandra, Caggìa, Veronica, Mestrot, Adrien, Guan, Hang   +11 more
core   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source