Results 101 to 110 of about 886,303 (268)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Breast Cancer Presentation, Treatment Patterns, and Progression‐Free Survival at a Tertiary Oncology Centre in Bangladesh: A Retrospective Study

Cancer Reports
Background Breast cancer remains a major cause of cancer‐related morbidity among women worldwide, with persistent disparities in diagnosis, treatment access, and outcomes across low‐ and middle‐income settings.
Qamruzzaman Chowdhury, Md Arifur Rahman, Ferdous Ara Begum, Ayasha Shiddika, Md Nurunnabi, Sharmin Akter Rupa, Mashud Parvez, S. M. Khodeza Nahar Begum, Salma Sultana   +8 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

HEART RATE VARIABILITY AND LEFT VENTRICLE VOLUMETRIC INDICES IN PATIENTS AFTER THE ACUTE Q-WAVE MYOCARDIAL INFARCTION

Евразийский Кардиологический Журнал, 2019
To estimate interrelations between heart rate variability (HRV) and left ventricle volumetric indices in patients after the acute Q-wave myocardial infarction (Q-AMI).
N. . Zakirov, Y. . Kevorkova, G. . Mullabaeva, A. . Kevorkov   +3 more
doaj  

Gastric Trichobezoar: A Case Report of a Young Adult From a Secondary Hospital

Clinical Case Reports
Key Clinical Message Trichobezoar is the pathological formation of a hair mass within the gastrointestinal tract, usually correlated with psychiatric conditions like trichotillomania and trichophagia.
Mohaned Altijani Abdalgadir Hamdnaalla, Mohammed Ali Mohammed Ali, Eltayeb Sabeil Abdalla Idris, Maisara Fathi Ahmed Salih, Heyam Abdelazim Abdelrahim Ali, Rame Taha Zeiada Taha, Loai Osman Elrofaie Osman   +6 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The Role of Sex in Ocular Biometry: A Large-Scale Study of Cataract Candidates in Greece

Ophthalmology and Therapy
Introduction Accurate intraocular lens (IOL) selection in cataract surgery relies on precise ocular biometry, yet variability between patients remains a challenge in achieving optimal refractive outcomes.
Dimitra Sakka, Athanasios Zisimopoulos, Efthymia Kalogera, Efstathios Athanasopoulos, Kalliopi Diamantopoulou, Ioannis Halkiadakis, Kalliroi Konstantopoulou, Christina Kourentis, Ioannis Markopoulos, Iakovos Michail, Efstratios Paroikakis, Vasileios Peponis, Michael Karampelas   +12 more
doaj   +1 more source

Specialization [PDF]

Postgraduate Medical Journal, 1954
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source