Results 1 to 10 of about 212,832 (300)

Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic β-cells

iScience, 2023
Summary: Loss of insulin-secreting β-cells in diabetes may be either due to apoptosis or dedifferentiation of β-cell mass. The ubiquitin-proteasome system comprising E3 ligase and deubiquitinases (DUBs) controls several aspects of β-cell functions.
Meenal Francis, Smitha Bhaskar, Saarwani Komanduri, Preethi Sheshadri, Jyothi Prasanna, Anujith Kumar   +5 more
doaj   +1 more source

Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning

iScience, 2023
Summary: Adipose tissue from pheochromocytoma patients acquires brown fat features, making it a valuable model for studying the mechanisms that control thermogenic adipose plasticity in humans. Transcriptomic analyses revealed a massive downregulation of
Moisés Castellá, Albert Blasco-Roset, Marion Peyrou, Aleix Gavaldà-Navarro, Joan Villarroya, Tania Quesada-López, Leyre Lorente-Poch, Juan Sancho, Florian Szymczak, Anthony Piron, Sonia Rodríguez-Fernández, Stefania Carobbio, Albert Goday, Pere Domingo, Antonio Vidal-Puig, Marta Giralt, Décio L. Eizirik, Francesc Villarroya, Rubén Cereijo   +18 more
doaj   +1 more source

Characterization of adipose depot-specific stromal cell populations by single-cell mass cytometry

iScience, 2022
Summary: The increased prevalence of obesity and metabolic diseases has heightened interest in adipose tissue biology and its potential as a therapeutic target.
Ju Hee Lee, Kafi N. Ealey, Yash Patel, Navkiran Verma, Nikita Thakkar, So Young Park, Jae-Ryong Kim, Hoon-Ki Sung   +7 more
doaj   +1 more source

Platelets reprogram monocyte functions by secreting MMP-9 to benefit postoperative outcomes following acute aortic dissection

iScience, 2023
Summary: Platelets have a great ability to modulate immune responses. Monocyte-platelet aggregates (MPAs) are associated with the pathogenesis of cardiac disease.
Wei-Yun Shen, Hui Li, An-Hui Zha, Ru-Yi Luo, Yan-Ling Zhang, Cong Luo, Ru-Ping Dai   +6 more
doaj   +1 more source

A ligand-receptor interactome atlas of the zebrafish

iScience, 2023
Summary: Studies in zebrafish can unravel the functions of cellular communication and thus identify novel bench-to-bedside drugs targeting cellular communication signaling molecules.
Milosz Chodkowski, Andrzej Zielezinski, Savani Anbalagan   +2 more
doaj   +1 more source

Single-cell transcriptomics reveals heterogeneity and intercellular crosstalk in human intervertebral disc degeneration

iScience, 2023
Summary: The complexity of the human intervertebral disc (IVD) has hindered the elucidation of the microenvironment and mechanisms underlying IVD degeneration (IVDD).
Dandan Wang, ZiZhang Li, Weimin Huang, Shengnan Cao, Liangyu Xie, Yuanzhen Chen, Huazhong Li, Lei Wang, Xiaoshu Chen, Jian-Rong Yang   +9 more
doaj   +1 more source

Identification and Characterization of Highly Fluorescent Pigment Cells in Embryos of the Arabian Killifish (Aphanius Dispar)

iScience, 2020
Summary: The Arabian killifish, Aphanius dispar, is a small tropical teleost fish living in wide range of habitats in sea water and fresh water in the Middle East.
Atyaf Hamied, Qusay Alnedawy, Ana Correia, Christian Hacker, Mark Ramsdale, Hisashi Hashimoto, Tetsuhiro Kudoh   +6 more
doaj   +1 more source

Phagosomal chloride dynamics in the alveolar macrophage

iScience, 2022
Summary: Acidification in intracellular organelles is tightly linked to the influx of Cl− counteracting proton translocation by the electrogenic V-ATPase.
Vladimir Riazanski, Gerardo Mauleon, Adriana M. Zimnicka, Si Chen, Deborah J. Nelson   +4 more
doaj   +1 more source

Lens regeneration in situ using hESCs-derived cells —similar to natural lens

iScience, 2023
Summary: Lens itself has limited regeneration functionality, thus we aimed to create regenerated lens with biological function to treat cataracts rather than the intraocular lens used in cataract surgery.
Xinyi Chen, Hanle Wang, Hui Chen, Ling Ren, Wei Wang, Jingjie Xu, Chenqi Luo, Peike Hu, Qiuli Fu, Ke Yao   +9 more
doaj   +1 more source

Changes in the hydrophobic network of the FliGMC domain induce rotational switching of the flagellar motor

iScience, 2023
Summary: The FliG protein plays a pivotal role in switching the rotational direction of the flagellar motor between clockwise and counterclockwise. Although we previously showed that mutations in the Gly-Gly linker of FliG induce a defect in switching ...
Tatsuro Nishikino, Atsushi Hijikata, Seiji Kojima, Tsuyoshi Shirai, Masatsune Kainosho, Michio Homma, Yohei Miyanoiri   +6 more
doaj   +1 more source