Results 111 to 120 of about 501,668 (378)
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
Homeostatic Eosinophils: Characteristics and Functions
Frontiers in Medicine, 2017 Eosinophils are typically considered to be specialized effector cells that are recruited to the tissues as a result of T helper type 2 (Th2) cell responses associated with helminth infections or allergic diseases such as asthma.
T. Marichal, Claire Mesnil, F. Bureau
semanticscholar +1 more source
Human dendritic cell subsets: An updated view of their ontogeny and functional specialization
European Journal of Immunology, 2022 AbstractHuman DCs have been divided into several subsets based on their phenotype and ontogeny. Recent high throughput single‐cell methods have revealed additional heterogeneity within human DC subsets, and new subpopulations have been proposed. In this review, we provide an updated view of the human DC subsets and of their ontogeny supported by recent
openaire +3 more sources
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Transcriptomic gene signatures measure satellite cell activity in muscular dystrophies
iScienceSummary: The routine need for myonuclear turnover in skeletal muscle, together with more sporadic demands for hypertrophy and repair, are performed by resident muscle stem cells called satellite cells.
Elise N. Engquist +5 more
doaj +1 more source
iScience, 2020 Summary: The neural retina and retinal pigment epithelium (RPE) maintain a symbiotic metabolic relationship, disruption of which leads to debilitating vision loss.
Tirthankar Sinha +2 more
doaj +1 more source
Synthesizing Functional Reactive Programs [PDF]
, 2019 Functional Reactive Programming (FRP) is a paradigm that has simplified the construction of reactive programs. There are many libraries that implement incarnations of FRP, using abstractions such as Applicative, Monads, and Arrows.
Finkbeiner, Bernd +3 more
core +1 more source
Immunity to Pathogens Taught by Specialized Human Dendritic Cell Subsets
Frontiers in Immunology, 2015 Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) that have a key role in immune responses because they bridge the innate and adaptive arms of the immune system.
J. Geginat +6 more
semanticscholar +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
iScienceSummary: During malaria infection, Plasmodium sporozoites, the fast-moving stage of the parasite, are injected by a mosquito into the skin of the mammalian host. In the skin, sporozoites need to migrate through the dermal tissue to enter the blood vessel.
Zhenhui Liu +9 more
doaj +1 more source