Results 11 to 20 of about 501,668 (378)
Cell–cell interfaces as specialized compartments directing cell function [PDF]
Nature Reviews Molecular Cell Biology, 2020 Cell-cell interfaces are found throughout multicellular organisms, from transient interactions between motile immune cells to long-lived cell-cell contacts in epithelia. Studies of immune cell interactions, epithelial cell barriers, neuronal contacts and sites of cell-cell fusion have identified a core set of features shared by cell-cell interfaces ...
Brian Belardi +4 more
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Specialized Antitumor Functions for Skin γδ T Cells [PDF]
The Journal of Immunology, 2018 A central role for T cells in an immune response was well known, and their functional characterization proceeded for many years in the absence of molecular identification of the TCR. It was known that T cells could only see Ags presented on the surface of another cell and that recognition of ...
Wendy L. Havran
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Distinct Functions of Specialized Dendritic Cell Subsets in Atherosclerosis and the Road Ahead [PDF]
Scientifica, 2014 Atherosclerotic vascular disease is modulated by immune mechanisms. Dendritic cells (DCs) and T cells are present within atherosclerotic lesions and function as central players in the initiation and modulation of adaptive immune responses. In previous years, we have studied the functional contribution of distinct DC subsets in disease development ...
Alma Zernecke
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Functional Specialization of Islet Dendritic Cell Subsets [PDF]
The Journal of Immunology, 2012 Abstract Dendritic cells (DC) play important roles in both tolerance and immunity to β cells in type 1 diabetes. How and why DC can have diverse and opposing functions in islets remains elusive. To answer these questions, islet DC subsets and their specialized functions were characterized.
Yaozhong Ding +6 more
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Subcellular Specialization of Mitochondrial Form and Function in Skeletal Muscle Cells [PDF]
Frontiers in Cell and Developmental Biology, 2021 Across different cell types and within single cells, mitochondria are heterogeneous in form and function. In skeletal muscle cells, morphologically and functionally distinct subpopulations of mitochondria have been identified, but the mechanisms by which the subcellular specialization of mitochondria contributes to energy homeostasis in working muscles
T. Bradley Willingham +3 more
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iScience, 2023 Summary: The complexity of the human intervertebral disc (IVD) has hindered the elucidation of the microenvironment and mechanisms underlying IVD degeneration (IVDD).
Dandan Wang +9 more
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Phenotypical and functional specialization of FOXP3+ regulatory T cells [PDF]
Nature Reviews Immunology, 2011 Forkhead box P3 (FOXP3)(+) regulatory T (T(Reg)) cells prevent autoimmune disease, maintain immune homeostasis and modulate immune responses during infection. To accomplish these tasks, T(Reg) cell activity is precisely controlled, and this requires T(Reg) cells to alter their migratory, functional and homeostatic properties in response to specific ...
Meghan A. Koch, Daniel J. Campbell
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Developmental Origin and Functional Specialization of Mast Cell Subsets [PDF]
Immunity, 2012 Mast cells (MCs) are constitutively present in most tissues and a distinct subset of MCs can also be induced upon host responses to inflammation. The hematopoietic lineage development of tissue MCs is unique compared to other myeloid-derived cells because it is early lineage progenitors, undetectable by histochemistry, that leave the bone marrow to ...
Michael F. Gurish, K. Frank Austen
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iScience, 2020 Summary: The Arabian killifish, Aphanius dispar, is a small tropical teleost fish living in wide range of habitats in sea water and fresh water in the Middle East.
Atyaf Hamied +6 more
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Phagosomal chloride dynamics in the alveolar macrophage
iScience, 2022 Summary: Acidification in intracellular organelles is tightly linked to the influx of Cl− counteracting proton translocation by the electrogenic V-ATPase.
Vladimir Riazanski +4 more
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