Results 11 to 20 of about 212,832 (300)
Antigen-presenting cells as specialized drivers of intestinal T cell functions [PDF]
ImmunityThe immune system recognizes a multitude of innocuous antigens from food and intestinal commensal microbes toward which it orchestrates appropriate, non-inflammatory responses. This process requires antigen-presenting cells (APCs) that induce T cells with either regulatory or effector functions.
Ranit Kedmi, Dan R. Littman
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Distinct Functions of Specialized Dendritic Cell Subsets in Atherosclerosis and the Road Ahead [PDF]
Scientifica, 2014 Atherosclerotic vascular disease is modulated by immune mechanisms. Dendritic cells (DCs) and T cells are present within atherosclerotic lesions and function as central players in the initiation and modulation of adaptive immune responses. In previous years, we have studied the functional contribution of distinct DC subsets in disease development ...
Alma Zernecke
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Zinc networks: the cell-specific compartmentalization of zinc for specialized functions [PDF]
bchm, 2012 Abstract Zinc (Zn2+) is the most abundant trace element in cells and is essential for a vast number of catalytic, structural, and regulatory processes. Mounting evidence indicates that like calcium (Ca2+), intracellular Zn2+ pools are redistributed for specific cellular functions.
Stephen R. Hennigar, Shannon L. Kelleher
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Functional Specialization of Islet Dendritic Cell Subsets [PDF]
The Journal of Immunology, 2012 Abstract Dendritic cells (DC) play important roles in both tolerance and immunity to β cells in type 1 diabetes. How and why DC can have diverse and opposing functions in islets remains elusive. To answer these questions, islet DC subsets and their specialized functions were characterized.
Na, Yin +6 more
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Subcellular Specialization of Mitochondrial Form and Function in Skeletal Muscle Cells [PDF]
Frontiers in Cell and Developmental Biology, 2021 Across different cell types and within single cells, mitochondria are heterogeneous in form and function. In skeletal muscle cells, morphologically and functionally distinct subpopulations of mitochondria have been identified, but the mechanisms by which the subcellular specialization of mitochondria contributes to energy homeostasis in working muscles
T. Bradley Willingham +3 more
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Developmental Origin and Functional Specialization of Mast Cell Subsets [PDF]
Immunity, 2012 Mast cells (MCs) are constitutively present in most tissues and a distinct subset of MCs can also be induced upon host responses to inflammation. The hematopoietic lineage development of tissue MCs is unique compared to other myeloid-derived cells because it is early lineage progenitors, undetectable by histochemistry, that leave the bone marrow to ...
Gurish, Michael F., Austen, K. Frank
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Functionally specialized junctions between endothelial cells of lymphatic vessels [PDF]
The Journal of Cell Biology, 2007 Recirculation of fluid and cells through lymphatic vessels plays a key role in normal tissue homeostasis, inflammatory diseases, and cancer. Despite recent advances in understanding lymphatic function (Alitalo, K., T. Tammela, and T.V. Petrova. 2005. Nature.
P. Baluk +10 more
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Phenotypical and functional specialization of FOXP3+ regulatory T cells [PDF]
Nature Reviews Immunology, 2011 Forkhead box P3 (FOXP3)(+) regulatory T (T(Reg)) cells prevent autoimmune disease, maintain immune homeostasis and modulate immune responses during infection. To accomplish these tasks, T(Reg) cell activity is precisely controlled, and this requires T(Reg) cells to alter their migratory, functional and homeostatic properties in response to specific ...
Daniel J, Campbell, Meghan A, Koch
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Lipid signalling enforces functional specialization of Treg cells in tumours
Nature, 2021 Regulatory T cells (Treg cells) are essential for immune tolerance1, but also drive immunosuppression in the tumour microenvironment2. Therapeutic targeting of Treg cells in cancer will therefore require the identification of context-specific mechanisms that affect their function.
Seon Ah Lim +11 more
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Functional Specialization of Skin Dendritic Cell Subsets in Regulating T Cell Responses [PDF]
Frontiers in Immunology, 2015 Dendritic cells (DC) are a heterogeneous family of professional antigen-presenting cells classically recognized as most potent inducers of adaptive immune responses. In this respect, Langerhans cells have long been considered to be prototypic immunogenic DC in the skin. More recently this view has considerably changed.
Clausen, Björn E., Stoitzner, Patrizia
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