Results 21 to 30 of about 503,791 (335)
iScience, 2023 Summary: The complexity of the human intervertebral disc (IVD) has hindered the elucidation of the microenvironment and mechanisms underlying IVD degeneration (IVDD).
Dandan Wang +9 more
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Developmental Origin and Functional Specialization of Mast Cell Subsets [PDF]
Immunity, 2012 Mast cells (MCs) are constitutively present in most tissues and a distinct subset of MCs can also be induced upon host responses to inflammation. The hematopoietic lineage development of tissue MCs is unique compared to other myeloid-derived cells because it is early lineage progenitors, undetectable by histochemistry, that leave the bone marrow to ...
Gurish, Michael F., Austen, K. Frank
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Functionally specialized junctions between endothelial cells of lymphatic vessels [PDF]
The Journal of Cell Biology, 2007 Recirculation of fluid and cells through lymphatic vessels plays a key role in normal tissue homeostasis, inflammatory diseases, and cancer. Despite recent advances in understanding lymphatic function (Alitalo, K., T. Tammela, and T.V. Petrova. 2005. Nature.
P. Baluk +10 more
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iScience, 2020 Summary: The Arabian killifish, Aphanius dispar, is a small tropical teleost fish living in wide range of habitats in sea water and fresh water in the Middle East.
Atyaf Hamied +6 more
doaj +1 more source
Phagosomal chloride dynamics in the alveolar macrophage
iScience, 2022 Summary: Acidification in intracellular organelles is tightly linked to the influx of Cl− counteracting proton translocation by the electrogenic V-ATPase.
Vladimir Riazanski +4 more
doaj +1 more source
Phenotypical and functional specialization of FOXP3+ regulatory T cells [PDF]
Nature Reviews Immunology, 2011 Forkhead box P3 (FOXP3)(+) regulatory T (T(Reg)) cells prevent autoimmune disease, maintain immune homeostasis and modulate immune responses during infection. To accomplish these tasks, T(Reg) cell activity is precisely controlled, and this requires T(Reg) cells to alter their migratory, functional and homeostatic properties in response to specific ...
Daniel J, Campbell, Meghan A, Koch
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Lipid signalling enforces functional specialization of Treg cells in tumours
Nature, 2021 Regulatory T cells (Treg cells) are essential for immune tolerance1, but also drive immunosuppression in the tumour microenvironment2. Therapeutic targeting of Treg cells in cancer will therefore require the identification of context-specific mechanisms that affect their function.
Seon Ah Lim +11 more
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Functional Specialization of Skin Dendritic Cell Subsets in Regulating T Cell Responses [PDF]
Frontiers in Immunology, 2015 Dendritic cells (DC) are a heterogeneous family of professional antigen-presenting cells classically recognized as most potent inducers of adaptive immune responses. In this respect, Langerhans cells have long been considered to be prototypic immunogenic DC in the skin. More recently this view has considerably changed.
Clausen, Björn E., Stoitzner, Patrizia
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The plant-pathogen haustorial interface at a glance [PDF]
, 2020 Many filamentous pathogens invade plant cells through specialized hyphae called haustoria. These infection structures are enveloped by a newly synthesized plant-derived membrane called the extrahaustorial membrane (EHM).
Bozkurt, Tolga O., Kamoun, Sophien
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Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells [PDF]
Immunity, 2008 Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs. We showed that CD14(+) DCs primed CD4(+) T cells into cells that induce naive B cells to switch isotype and become plasma cells.
Klechevsky, Eynav +12 more
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