Results 21 to 30 of about 212,832 (300)

Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells [PDF]

Immunity, 2008
Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs. We showed that CD14(+) DCs primed CD4(+) T cells into cells that induce naive B cells to switch isotype and become plasma cells.
Klechevsky, Eynav, Morita, Rimpei, Liu, Maochang, Cao, Yanying, Coquery, Sebastien, Thompson-Snipes, LuAnn, Briere, Francine, Chaussabel, Damien, Zurawski, Gerard, Palucka, A. Karolina, Reiter, Yoram, Banchereau, Jacques, Ueno, Hideki   +12 more
openaire   +2 more sources

Quantitative proteomics and RNA-sequencing of mouse liver endothelial cells identify novel regulators of BMP6 by iron

iScience, 2023
Summary: Hepcidin is the master hormone governing systemic iron homeostasis. Iron regulates hepcidin by activating bone morphogenetic protein (BMP)6 expression in liver endothelial cells (LECs), but the mechanisms are incompletely understood.
Allison L. Fisher, Chia-Yu Wang, Yang Xu, Sydney Phillips, Joao A. Paulo, Beata Małachowska, Xia Xiao, Wojciech Fendler, Joseph D. Mancias, Jodie L. Babitt   +9 more
doaj   +1 more source

The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function

eLife, 2014
Mesenchymal stem cells (MSCs) and osteolineage cells contribute to the hematopoietic stem cell (HSC) niche in the bone marrow of long bones. However, their developmental relationships remain unclear. In this study, we demonstrate that different MSC populations in the developing marrow of long bones have distinct functions.
Joan Isern, Andrés García‐García, A. MARTIN, Lorena Arranz, Daniel Martín-Pérez, Carlos Torroja, Fátima Sánchez‐Cabo, Simón Méndez‐Ferrer   +7 more
openalex   +5 more sources

IP3-Dependent Ca2+ Oscillations Switch into a Dual Oscillator Mechanism in the Presence of PLC-Linked Hormones

iScience, 2020
Summary: Ca2+ oscillations that depend on inositol-1,4,5-trisphosphate (IP3) have been ascribed to biphasic Ca2+ regulation of the IP3 receptor (IP3R) or feedback mechanisms controlling IP3 levels in different cell types.
Paula J. Bartlett, Ielyaas Cloete, James Sneyd, Andrew P. Thomas   +3 more
doaj   +1 more source

Effect of mitophagy in the formation of osteomorphs derived from osteoclasts

iScience, 2023
Summary: Osteoclasts are specialized multinucleated giant cells with unique bone-destroying capacities. A recent study revealed that osteoclasts undergo an alternative cell fate by dividing into daughter cells called osteomorphs. To date, no studies have
Tingben Huang, Yuchen Wang, Zhou Yu, Xiaoyan Miao, Zhiwei Jiang, Ke Yu, Mengdie Fu, Kaichen Lai, Ying Wang, Guoli Yang   +9 more
doaj   +1 more source

Optogenetic activation of UCP1-dependent thermogenesis in brown adipocytes

iScience, 2023
Summary: Brown adipocytes are unique in that they expend energy and produce heat to maintain euthermia through expression of uncoupling protein-1 (UCP1).
Chad C. Doucette, Daniel C. Nguyen, Davide Barteselli, Sophia Blanchard, Mason Pelletier, Devesh Kesharwani, Ed Jachimowicz, Su Su, Michele Karolak, Aaron C. Brown   +9 more
doaj   +1 more source

Functional Specialization of Memory Th Cells Revealed by Expression of Integrin CD49b [PDF]

The Journal of Immunology, 2006
Abstract Infection or immunization induces heterogeneous memory T cell subsets, but their origin and protective value against infection are unclear. In this study, we report the functional characterization of two memory Th subsets, defined by expression of integrin CD49b. Stable CD49b expression is induced in up to one-half of all memory
Kassiotis, George, Gray, David, Kiafard, Ziba, Zwirner, Joerg, Stockinger, Brigitta   +4 more
openaire   +3 more sources

Resistin targets TAZ to promote osteogenic differentiation through PI3K/AKT/mTOR pathway

iScience, 2023
Summary: Osteogenic differentiation (OD) of bone marrow mesenchymal stem cells (BMSCs) contributes significantly to the regeneration of bone defects.
JingJing Shang, Zhentang Yu, Chengwei Xiong, Junjie Zhang, Jinhong Gong, Changlin Yu, Yong Huang, Xindie Zhou   +7 more
doaj   +1 more source

New insights into transcriptome variation during cattle adipocyte adipogenesis by direct RNA sequencing

iScience, 2023
Summary: We performed direct RNA sequencing (DRS) together with PCR-amplified cDNA long and short read sequencing for cattle adipocyte at different stages.
Lingwei Peng, Xiaolian Zhang, Yuqin Du, Fan Li, Jiazheng Han, Oujin Liu, Shoulu Dai, Xiang Zhang, George E. Liu, Liguo Yang, Yang Zhou   +10 more
doaj   +1 more source

Molecular Mechanisms of T Helper Cell Differentiation and Functional Specialization

Immune Network, 2023
Th cells, which orchestrate immune responses to various pathogens, differentiate from naïve CD4 T cells into several subsets that stimulate and regulate immune responses against various types of pathogens, as well as a variety of immune-related diseases.
openaire   +2 more sources