Results 41 to 50 of about 501,668 (378)

Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling [PDF]

, 2012
The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets of closely associated polarized epithelial cells requires the assembly of specialized cell ...
Pieters, Tim, van Hengel, Jolanda, Van Roy, Frans   +2 more
core   +2 more sources

Functions of actin in mouse oocytes at a glance

Journal of Cell Science, 2018
Gametes undergo a specialized and reductional cell division termed meiosis. Female gametes (oocytes) undergo two rounds of meiosis; the first meiotic division produces the fertilizable egg, while the second meiotic division occurs upon fertilization ...
Julia Uraji, K. Scheffler, M. Schuh
semanticscholar   +1 more source

Tetraspanin CD53 Promotes Lymphocyte Recirculation by Stabilizing L-Selectin Surface Expression

iScience, 2020
Summary: Tetraspanins regulate key processes in immune cells; however, the function of the leukocyte-restricted tetraspanin CD53 is unknown. Here we show that CD53 is essential for lymphocyte recirculation.
Maria C. Demaria, Louisa Yeung, Rens Peeters, Janet L. Wee, Masa Mihaljcic, Eleanor L. Jones, Zeyad Nasa, Frank Alderuccio, Pamela Hall, Brodie C. Smith, Katrina J. Binger, Gunther Hammerling, Hang Fai Kwok, Andrew Newman, Ann Ager, Annemiek van Spriel, Michael J. Hickey, Mark D. Wright   +17 more
doaj   +1 more source

Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells [PDF]

Immunity, 2008
Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs. We showed that CD14(+) DCs primed CD4(+) T cells into cells that induce naive B cells to switch isotype and become plasma cells.
Maochang Liu, Yoram Reiter, Francine Briere, Lu Ann Thompson-Snipes, Rimpei Morita, Hideki Ueno, Yanying Cao, Eynav Klechevsky, Eynav Klechevsky, Sebastien Coquery, A. Karolina Palucka, Gerard Zurawski, Damien Chaussabel, Jacques Banchereau   +13 more
openaire   +3 more sources

CircMAPK9 promotes adipogenesis through modulating hsa-miR-1322/FTO axis in obesity

iScience, 2023
Summary: Circular RNA (circRNA) is a special category of non-coding RNA that has garnered increasing attention in the exploration of lipid metabolism. However, the functional regulation mechanisms of circRNAs in obesity diseases remain unclear.
Shuai Chen, Peng Song, Yu Wang, Zeng Wang, Jiaming Xue, Yicheng Jiang, Yan Zhou, Jie Zhao, Liming Tang   +8 more
doaj   +1 more source

Novel specialized cell state and spatial compartments within the germinal center

Nature Immunology, 2020
Within germinal centers (GCs), complex and highly orchestrated molecular programs must balance proliferation, somatic hypermutation and selection to both provide effective humoral immunity and to protect against genomic instability and neoplastic ...
Domenick E. Kennedy, Michael K. Okoreeh, M. Maienschein-Cline, Junting Ai, M. Veselits, Kaitlin C. McLean, Yogesh Dhungana, Hong Wang, Junmin Peng, H. Chi, M. Mandal, M. Clark   +11 more
semanticscholar   +1 more source

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia [PDF]

, 2003
Vascular endothelial growth factor (VEGF-A) is a major regulator of blood vessel formation and function. it controls several processes in endothelial cells, such as proliferation, survival, and migration, but it is not known how these are coordinately ...
Abramsson, A, Alitalo, K, Betsholtz, C, Fruttiger, M, Gerhardt, H, Golding, M, Jeltsch, M, Lundkvist, A, Mitchell, C, Ruhrberg, C, Shima, D   +10 more
core   +2 more sources

Human Periodontal Stem Cells Release Specialized Proresolving Mediators and Carry Immunomodulatory and Prohealing Properties Regulated by Lipoxins

Stem Cells Translational Medicine, 2015
Unresolved inflammation and tissue destruction are underlying mechanisms of periodontitis, which is linked to dysregulated polymorphonuclear neutrophil (PMN) functions.
E. Cianci, A. Recchiuti, O. Trubiani, F. Diomede, M. Marchisio, S. Miscia, R. Colas, Jesmond Dalli, C. Serhan, M. Romano   +9 more
semanticscholar   +1 more source

Molecular Mechanisms of T Helper Cell Differentiation and Functional Specialization

Immune Network, 2023
Th cells, which orchestrate immune responses to various pathogens, differentiate from naïve CD4 T cells into several subsets that stimulate and regulate immune responses against various types of pathogens, as well as a variety of immune-related diseases.
openaire   +2 more sources

Lipid signalling enforces functional specialization of Treg cells in tumours

Nature, 2021
Regulatory T cells (Treg cells) are essential for immune tolerance1, but also drive immunosuppression in the tumour microenvironment2. Therapeutic targeting of Treg cells in cancer will therefore require the identification of context-specific mechanisms that affect their function.
Seon Ah Lim, Jun Wei, Thanh-Long M. Nguyen, Hao Shi, Wei Su, Gustavo Palacios, Yogesh Dhungana, Nicole M. Chapman, Lingyun Long, Jordy Saravia, Peter Vogel, Hongbo Chi   +11 more
openaire   +4 more sources